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Comparison of Adalimumab and Tofacitinib in the Treatment of Active Takayasu Arteritis — ADATOFTAK  

Takayasu Arteritis Clinical Trial

Official title:
An Open-label，Randomized, Controlled, Multicenter Study of Adalimumab and Tofacitinib in the Treatment of Active Takayasu Arteritis

Clinical Trial Summary

This is a prospective,open-labelled,multi-center,randomized clinical trial.It compares the clinical efficacy and safety of there 2 drugs in the treatment of relapse active Takayasu's arteritis patients.

Clinical Trial Description

In this study, 100 relapse Takayasu's arteritis patients will be enrolled. Patients are randomized into the adalimumab treatment group and tofacitinib treatment.Patients will also be treated with reduced dose of glucocorticoid at the same time. The primary end point is the percentage of patients who are in complete response at week 12 and maintain in complete response at week 78. The efficacy will be evaluated at week 12, 24, 36, 52 and 78. If the patient does not respond to one drug at week 24, then the investigator will shift the treatment to another intervention. Safety is also monitored during the study. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05151848
Study type Interventional
Source Chinese SLE Treatment And Research Group
Contact Xinping Tian, MD
Phone 8613691165939
Email tianxp6@126.com
Status Recruiting
Phase Phase 4
Start date January 5, 2022
Completion date January 15, 2026
View Details
See also
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