The Effect of Tai Chi Exercise Among Elders With Sarcopenia

Tai Chi Clinical Trial

Official title:

The Effect of Tai Chi Exercise Among Elders With Sarcopenia

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05145036
• Other study ID #: CMUH110-REC2-107
• Status: Completed
• Phase: N/A
• Start date: December 1, 2021
• Est. completion date: September 28, 2022

Study information

• Verified date: January 2023
• Source: China Medical University Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Sarcopenia has been defined as a disease which presented as low muscles strength, low muscle quantity or quality and low physical activity. The prevalence of sarcopenia is increasing with the age and it is also included in one of geriatric syndromes. Several criteria have been mentioned for diagnosis of sarcopenia, such as European Working Group on Sarcopenia in Older People (EWGSOP)、Foundation for the National Institutes of Health Biomarkers Consortium Sarcopenia Project (FNIH) and Asian Working Group for Sarcopenia (AWGS).

In European, the prevalence rate of sarcopenia is 9.25-18%; 5-7% Canadian and 14.4% Taiwanese elders have been diagnosed as sarcopenia, respectively. The sarcopenia has been found its relationship with adverse outcomes of fall down, fracture, disability, and death. The cytokines and decline in anabolic hormones play a role in the pathogenesis of sarcopenia. Tai Chi exercise is one of Qigong and well-popular in Chinese population, and is helpful to integration of body movements. Tai Chi exercise is less complicated and emphasized people's awareness of self-care which presented the relationship between human and nature. Tai Chi exercise could improve muscle performance, balance and have the benefit for fall down prevention in the elders and patients with frailty. Furthermore, Tai Chi has been found that it also could improve the muscle power and power strength in sarcopenic elders by team training. Furthermore, immune makers of inflammation process have been noted their diminishments by Qigong intervention.

The aim of this study is to investigate the effect of Tai Chi exercise in sarcopenic elders through practicing at home. The differences of muscles strength, muscle quantity or quality and physical activity after interventions would be recorded and analyzed. The cytokines related to the sarcopenia process would also be sampled.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 60
• Est. completion date: September 28, 2022
• Est. primary completion date: April 29, 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 60 Years and older

Eligibility

Inclusion Criteria:

• Age 60 or older;

• With a diagnosis of sarcopenia [defined as EWGSOP-2] (6);

• Without planned exercise program or unplanned admission in 6 months;

• Could tolerate tests of muscle power and strength.

Exclusion Criteria:

• Uncontrolled diabetes mellitus;

• Uncontrolled cardiovascular diseases;

• Uncontrolled hypertension;

• Knee or hip prosthesis, pacemaker, fracture in the previous 6 months,

• Critical cognitive (MMSE<23)

• Mini Nutritional Assessment (MNA <17)

• Physical dysfunctions that could not tolerate our tests

Related Conditions & MeSH terms

• Sarcopenia
• Tai Chi

Intervention

Behavioral:
• Tai-Chi
Tai Chi exercise could improve muscle performance, balance and have the benefit for fall down prevention in the elders and patients with frailty.
• Comprehensive training
There are 3 exercises. Each session consisted of 10 minutes of warm-up, 40 minutes of Tai Chi, and 10 minutes of cool down.

Locations

Country	Name	City	State
Taiwan	China Medical University Hospital	Taichung

Sponsors (1)

Lead Sponsor	Collaborator
China Medical University Hospital

Country where clinical trial is conducted

Taiwan, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Appendicular skeletal muscle mass in kilograms	The appendicular skeletal muscle mass is evaluated by bioelectrical impedance (BIA) analysis	baseline
Primary	Change from baseline appendicular skeletal muscle mass at 8 weeks	The appendicular skeletal muscle mass is evaluated by bioelectrical impedance (BIA) analysis	8 weeks
Primary	Hand grip in kilograms	The muscle strength is evaluated with the hand-grip strength (kg) by dynamometer	baseline
Primary	Hand grip in kilograms	The muscle strength is evaluated with the hand-grip strength (kg) by dynamometer	8 weeks
Primary	Times Chair-stand test (5-CST) in minutes	The 5CST is evaluated by recording the total time that patient repeat 5 times stand and sit motion from chair	baseline
Primary	Times Chair-stand test (5-CST) in minutes	The 5CST is evaluated by recording the total time that patient repeat 5 times stand and sit motion from chair	8 weeks