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Role of Eosinophil in Fibrogenesis of Systemic Sclerosis — EOFIB-SSC  

Systemic Sclerosis Clinical Trial

Official title:
Role of Blood and Tissue Eosinophils in the Fibrogenesis of Systemic Sclerosis

Clinical Trial Summary

Eosinophils are involved in tissue remodeling and fibrosis in many inflammatory diseases. Systemic sclerosis (SSc) is an autoimmune disease with fibrotic skin and lung complications. The profibrosing properties and data from the SSc literature suggest a possible role of the eosinophils in the process of fibrogenesis of SSc.

Clinical Trial Description

it will assess the activation state of blood eosinophils in SSc patients compared to healthy controls (ECP production in vitro, surface activation markers, whole transcriptome array, ..). it will also study skin eosinophils and their recruitment (extracellular eosinophil granules, eotaxins production in skin, ..) ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03816189
Study type Observational
Source University Hospital, Lille
Contact
Status Active, not recruiting
Phase
Start date October 3, 2018
Completion date December 2021
View Details
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