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Allogeneic Mesenchymal Stem Cells Transplantation for Systemic Sclerosis (SSc)

Systemic Sclerosis Clinical Trial

Clinical Trial Summary

This study will explore safety and efficacy of allogeneic mesenchymal stem cells transplantation (MSCT) to treat patients with diagnosis of systemic sclerosis(SSc) who have been resistant to multiple standard treatments. The underlying hypothesis is that the SSc condition is caused by an abnormal immune homeostasis that can be restored by MSCT.

Clinical Trial Description

- To test a new approach using allogeneic derived mesenchymal stem cell based therapy (MSCT) to treat refractory SSc

- To determine the disease-free survival in SSc patients treated with MSCT

- To assess adverse events of allogeneic MSC transplantation

- To assess the association of remission for organ function, clinical score and SSc serology levels at baseline with disease-free survival ;

Study Design

Allocation: Non-Randomized, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT00962923
Study type Interventional
Source The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Contact Lingyun Sun, MD
Phone +86-25-83105219
Email lingyunsun2001@yahoo.com.cn
Status Recruiting
Phase Phase 1/Phase 2
Start date August 2009
Completion date December 2011
View Details
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