Systemic Lupus Erythematosus Clinical Trial
Official title:
Telangiectatic Palmoplantar Keratoderma in Systemic and Subacute Lupus Erythematosus : to a Form of Lichen Planus-like Lupus Erythematosus ?
Palmoplantar keratoderma (PPK) associated to livid telangiectatic erythema during systemic lupus erythematosus (SLE) and subacute cutaneous lupus erythematosus (SCLE) is a rare phenomenon seldom reported in literature. The investigators hypothesize that clinic-immunologic assessment and detailed investigation of cutaneous biopsy specimen of PPK and erythema of patients suffering from SLE and SCLE could lead to determine more precisely nosological settings of this injury. Report the different therapeutics with efficacy assessment could be helpful to highlight useful treatment for these patients.
Context: Palmoplantar keratoderma (PPK) associated to livid telangiectatic erythema during
systemic lupus erythematosus (SLE) is a rare phenomenon seldom reported in literature. To our
knowledge no case has been described in subacute cutaneous lupus erythematosus (SCLE) so far.
Pathogeny and etiologic origin are not clear: it could be no-specific cutaneous manifestation
of SLE, verrucous chilblain lupus, lichen planus, discoid lupus erythematosus lesions,
overlap syndrome or coexistence of both diseases.
Objective:
1. Determine clinical immunological and histopathological features of patients with PPK and
livid telangiectatic erythema-associated suffering from SLE and SCLE
2. Describe the different therapeutics used and efficacy assessment Methods: Multicentric
retrospective descriptive study reporting 14 patients with SLE or SCLE suffering from an
acral livid erythematosus keratoderma, with clinical data regarding lupus erythematosus
and acral keratoderma, immunological blood samples findings and histopathological
results of keratoderma and livid erythema biopsies with direct immunofluorescence if
performed. The treatments set down in order to heal are noted followed by efficacy
assessment: total failure, partial remission, complete remission.
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