Systemic Lupus Erythematosus Clinical Trial
Official title:
Effects of an Aerobic Exercise Intervention Program on Arterial Stiffness and Inflammation in Women With Systemic Lupus Erythematosus
Patients with Systemic Lupus Erythematosus (SLE) have increased arterial stiffness, which
leads to cardiovascular diseases (CVD) of arteriosclerotic origin, which are the main cause
of mortality in these patients. Exercise is a modifiable factor that reduces cardiovascular
mortality and associated risk factors in the general population. Preliminary studies suggest
that exercise may improve endothelial function and lipid profile in patients with SLE.
However, whether meeting the international physical activity guidelines from the American
College of Sports Medicine (ACSM; i.e. ≥150 min / week of moderate to vigorous intensity
physical activity) can improve arterial stiffness (subclinical atherosclerosis marker) and
inflammation is unknown.
The primary aim of this study is to assess the effect of an exercise program based on meeting
the ACSM physical activity guidelines on arterial stiffness and inflammation in patients with
SLE.
The secondary aim is to assess the effect of an exercise program based on meeting the ACSM
physical activity guidelines on endothelial function, oxidative stress, as well as other
cardiometabolic risk factors, physical fitness, health-related quality of life, and other
psychosocial outcomes.
Our hypothesis is that meeting the ACSM guidelines will improve arterial stiffness and
inflammation in patients with SLE.
The study is a non-randomized clinical trial. To minimize selection bias, participants in the
intervention and control groups will be matched by age, BMI, and disease activity (SLEDAI),
which are important contributors to arterial stiffness.
n/a
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