The Diagnostic Performance of Tilt Test in Athletes

Syncope Clinical Trial

Official title:

The Diagnostic Performance of Tilt Test in Athletes and a Novel Strategy for Its Improvement

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02316860
• Other study ID #: sportscardiology
• Status: Completed
• Phase: N/A
• First received: December 6, 2014
• Last updated: October 25, 2017
• Start date: October 2014
• Est. completion date: December 2014

Study information

• Verified date: October 2017
• Source: Aristotle University Of Thessaloniki
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

In the present study the investigators evaluate the sensitivity and specificity of passive tilt test in athletes, as well as their haemodynamic responses and autonomic nervous system activity during head-up tilt. Moreover, the investigators try to apply a novel algorithm for the improvement of diagnostic yield of tilt test in athletes.

Description:

We examine athletes with a history of reflex syncope and athletes without history of reflex syncope.All subjects undergo a tilt test, for the evaluation of haemodynamics, heart rate variability (HRV) and baroreflex sensitivity.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 140
• Est. completion date: December 2014
• Est. primary completion date: December 2014
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 14 Years to 40 Years

Eligibility

Inclusion Criteria:

• 14-40 years old,

• more than 5 years of exercise training experience and competition at a regional level at different sports

Exclusion Criteria:

• smoking,

• recent alcohol consumption,

• presence of any chronic disease and use of drugs

Related Conditions & MeSH terms

• Syncope

Intervention

Other:
• Passive tilt test
Passive tilt test (without pharmacological provocation). After a horizontal supine rest period of 5 min, the tilt table was inclined at 60° head-up position for 30 min. A positive response was defined according to the European Society of Cardiology guidelines for the diagnosis and management of syncope

Locations

Country	Name	City	State
Greece	Laboratory of Sports Medicine, Sports Medicine Division, Aristotle University of Thessaloniki, Thessaloniki, Greece	Thessaloniki

Sponsors (1)

Lead Sponsor	Collaborator
Aristotle University Of Thessaloniki

Country where clinical trial is conducted

Greece, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	sensitivity and specificity of tilt test in athletes as measured by the occurence of syncope/presyncope during tilt test	sensitivity = number of subjects with syncope/presyncope during tilt test/ number of subjects with a history of reflex syncope, specificity = number of subjects without syncope/presyncope during tilt test/ number of subjects without history of reflex syncope	30 min
Secondary	Parameters of haemodynamics during tilt test	We investigate whether the mean values of parameters of haemodynamics during tilt test can discriminate between athletes with a history of reflex syncope and those without history of syncope	30 min
Secondary	Parameters of heart rate variability during tilt test	We investigate whether the mean values of parameters of heart rate variability during tilt test can discriminate between athletes with a history of reflex syncope and those without history of syncope	30 min
Secondary	Parameters of baroreflex sensitivity during tilt test	We investigate whether the mean values of parameters of baroreflex sensitivity during tilt test can discriminate between athletes with a history of reflex syncope and those without history of syncope	30 min