Surgical Site Infection Clinical Trial
Official title:
Effects of Photodynamic Therapy on the Human Inguinal Skin Microbiome to Improve Antiseptic Effect - Pilot 3
The overarching aim of this research project is to prevent orthopedic implant-associated infections. This study aims to investigate if PDT has an effect on bacterial skin colonization in order to improve skin antisepsis strategies for the prevention of surgical site infections.
Status | Recruiting |
Enrollment | 20 |
Est. completion date | December 31, 2023 |
Est. primary completion date | September 1, 2023 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 18 Years to 100 Years |
Eligibility | Inclusion Criteria: - Healthy male and female participants = 18 years who volunteer for the pilot study, in which a routine photodynamic treatment at the Department of Dermatology will be performed and effect of skin colonization will be analyzed, and who signed an informed consent (after information about the project) Exclusion Criteria: - Pregnant and breastfeeding women - Participants with inability to follow the procedures of the study, e.g. due to language problems, psychological disorders, dementia, etc., - Participants taking antibiotics in the 14 days prior to PDT or until follow-up at 21 days - Participants who received oral retinoid therapy within the last 6 months - Participants who received anti-inflammatory agents as Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) within the 14 days prior and after the PDT - Participants taking any photosensitizing drugs within 4 weeks prior to PDT - Participants who had a history of photosensitivity disorder - Fitzpatrick's skin phototype V-VI |
Country | Name | City | State |
---|---|---|---|
Switzerland | University Hospital of Zurich | Zurich |
Lead Sponsor | Collaborator |
---|---|
University of Zurich |
Switzerland,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Culture results of skin swabs | Quantitative evaluation of bacterial density and species from skin swabs taken before PDT, immediately after PDT, and after after skin antisepsis using culture technique | within 10 days after PDT |
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