Surgery With General Anesthesia Clinical Trial
Official title:
Validation of the Effect of Propofol and Opiates Closed-loop Administration Device During Anesthesia and Sedation
Sleeping medication and analgesia are standard administered during anesthesia. Sleeping
medication, Propofol (Diprivan, AstraZeneca), and analgesia, Remifentanil (GlaxoSmithKline),
are most frequently used In the University Hospital Ghent.
The clinical effect of administration of pharmaca can be measured in the changes of
heartbeat, blood pressure, respiration and the changes of brain activity by registering EEG.
These measurements are performed standard, to secure the safety of the patient.
The heartbeat and the EEG will be measured by non invasive adhesive electrodes on the skin
of the patient.
The blood pressure will be measured by non invasive blood pressure cuff around the arm and
the respiration parameters will be measured by non invasive spirometry, which are all
standard available on a anesthesia device.
Most of the pharmaca are administered by a fixed dosage schedule based on the patient's
weight.
A more individualized administration of this pharmaca could lead to a better anesthesia
quality.
Since considerable time, we know that a computer-controlled administration of these products
by automatic coupling between the measured effects and the "spuit"pump to administer the
product, could lead to a better administration, optimalisation of the administered dose,
because the patients individual effect of the administration can be taken in consideration.
This device is called the "closed-loop system". The department of Anesthesia has already
proofed the utility of the device for automatic administration of Propofol and opiates in
small specific patient groups.
n/a
Observational Model: Cohort, Time Perspective: Prospective