Supratentorial Neoplasms Clinical Trial
Official title:
Can Mannitol Increments Provide More Brain Relaxation in Patients Undergoing Craniotomy for Supratentorial Brain Tumor Removal?
Mannitol is widely used in patients with elevated intracranial pressure. In neurosurgical field, especially in large size or with brain edema, it is necessary to decrease brain volume to facilitate surgical approach. In general, 0.25 -1.5g of mannitol per kilogram has been known to decrease ICP effectively. But there are some debates in regard to appropriate dose of mannitol.
Previous meta-analysis reported that mannitol has dose-response relationship with
intracranial pressure. Another study of Sorani showed dose-response relationship between
mannitol and intracranial pressure (ICP) in traumatic brain injury patients.
In this study, authors would investigate that mannitol increments can provide more brain
relaxation in patients undergoing craniotomy for supratentorial brain tumor removal.
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Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Caregiver, Outcomes Assessor), Primary Purpose: Supportive Care
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