Supranuclear Palsy, Progressive Clinical Trial
Official title:
Study of the Distractibility Syndrome in Patients With Progressive Supranuclear Palsy
NCT number | NCT00139373 |
Other study ID # | RBM0323 |
Secondary ID | |
Status | Recruiting |
Phase | Phase 2 |
First received | August 30, 2005 |
Last updated | September 12, 2007 |
The syndrome of distractibility is a behavioral disorder induced by a lesion or a dysfunction of the frontal lobe. This sign is frequent in patients with progressive supranuclear palsy (PSP), a neurodegenerative disorder with severe neuronal loss in the prefrontal cortex and cholinergic systems, in particular in the Meynert basalis nucleus. This could participate in the occurrence of the distractibility in these patients. The aim of this study is to evaluate the effect of the donepezil, an anticholinesterase, on the distractibility in PSP patients, by using oculomotor and neuropsychological assessments.
Status | Recruiting |
Enrollment | 16 |
Est. completion date | |
Est. primary completion date | |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 30 Years to 80 Years |
Eligibility |
Inclusion Criteria: - Patients with PSP - Age > 30 years old - Disease duration < 5 years - Mini mental state (MMS) > 24 - Antisaccades %: 40-80% Exclusion Criteria: - Other parkinsonian syndromes - MMS < 24 |
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double-Blind, Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
France | Centre d'Investigation Clinique-HÔPITAL PITIÉ-SALPETRIERE | Paris |
Lead Sponsor | Collaborator |
---|---|
Groupe Hospitalier Pitie-Salpetriere | Institut National de la Santé Et de la Recherche Médicale, France |
France,
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