Supplementation Clinical Trial
Official title:
The Effect of Caffeine and Paraxantine Kinetics on Exercise Performance and Psychophysical State in Athletes After Ingestion of Mono- or Multi-ingredient Caffeine-containing Supplements
The study aims at assessing the relation between caffeine (CAF) and paraxanthine (PAX) kinetics after acute ingestion of caffeine (3 mg/kg body mass) in the form or mono- or multi-ingredient preparations and CrossFit®-specific performance or selected indicators of psychophysiological state. Blood indicators of muscle damage/recovery, acid-base balance and electrolytes levels will be evaluated. The impact of genetic variations in the polymorphisms rs5751876 in ADORA2A gene and rs762551 in CYP1A2 on CAF/PAX kinetics will be considered.
Status | Recruiting |
Enrollment | 25 |
Est. completion date | July 30, 2024 |
Est. primary completion date | July 29, 2024 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Male |
Age group | 18 Years to 40 Years |
Eligibility | Inclusion Criteria: - written informed consent from all participants before the study, - a current medical clearance to practice sports, - training experience any sport discipline = 5 years and training experience in HIFT = 2 years, - performing =3 training units per week, - participating in CrossFit® competitions at least once a year. Exclusion Criteria: - current injury, - any health-related contraindication, - declared general feeling of being unwell, - unwilling to follow the study protocol, - serious disease or metabolic problems, - smoking and tobacco use, - presence of infectious disease in the previous 4 weeks of the study. |
Country | Name | City | State |
---|---|---|---|
Poland | Department of Sports Dietetics, Poznan University of Physical Education | Poznan |
Lead Sponsor | Collaborator |
---|---|
Poznan University of Physical Education | National Science Centre, Poland, Poznan University of Life Sciences |
Poland,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | The effect of acute ingestion of the same dose of caffeine (3 mg/kg BM) in form of 3 different preparations on discipline-specific performance | Total number of repetitions in Fight Gone Bad test and number or repetitions in rounds 1 - 3 | 60 minutes after ingestion of tested supplements/placebo | |
Secondary | The effect of acute ingestion of the same dose of caffeine (3 mg/kg BM) in form of 3 different preparations on blood and saliva caffeine and its metabolites levels | Blood and saliva CAF and PAX concentrations (µmol/L) | Pre-ingestion and within 90 minutes after ingestion of tested supplements/placebo | |
Secondary | The effect of acute ingestion of the same dose of caffeine (3 mg/kg BM) in form of 3 different preparations on reaction time | Reaction time (s) | Pre-ingestion and within 90 minutes after ingestion of tested supplements/placebo | |
Secondary | The effect of acute ingestion of the same dose of caffeine (3 mg/kg BM) in form of 3 different preparations on postural stability | CoP sway area (mm2) | Pre-ingestion and within 90 minutes after ingestion of tested supplements/placebo | |
Secondary | The effect of acute ingestion of the same dose of caffeine (3 mg/kg BM) in form of 3 different preparations on subjective levels/feelings of "energy", alertness, focus, fatigue | Likert scale 1 - 5 | Pre-ingestion and within 90 minutes after ingestion of tested supplements/placebo | |
Secondary | The effect of acute ingestion of the same dose of caffeine (3 mg/kg BM) in form of 3 different preparations on the Rate of Perceived Exertion (RPE) | RPE evaluated via Borg scale (units: 6 - 20) | Pre-ingestion and within 90 minutes after ingestion of tested supplements/placebo | |
Secondary | The effect of acute ingestion of the same dose of caffeine (3 mg/kg BM) in form of 3 different preparations on selected blood markers | Blood bicarbonate (mmol/L), lactate (mmol/L), anion gap (mmol/L), H+ (mmol/L), base excess (mmol/L), creatinine (mmol/L), and myoglobin (mmol/L), electrolytes [Ca2+, Na+, K+, Cl-] (mmol/L) | Pre-ingestion and within 90 minutes after ingestion of tested supplements/placebo | |
Secondary | The effect of acute ingestion of the same dose of caffeine (3 mg/kg BM) in form of 3 different preparations on blood indicators of muscle damage/recovery | Activity of creatine kinase (U/L), lactate dehydrogenase (U/L), aspartate aminotransferase (U/L), alanine aminotransferase (U/L) | Pre-ingestion and within 90 minutes after ingestion of tested supplements/placebo |
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