The Effect of β-hydroxy-β-methylbutyrate Supplementation on Physical Capacity and Body Composition in Trained Athletes

Supplementation Clinical Trial

Official title:

The Effect of β-hydroxy-β-methylbutyrate (HMB) Supplementation on Physical Capacity and Body Composition in Trained Athletes

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03028649
• Other study ID #: NN312262340
• Status: Completed
• Phase: Phase 3
• First received: January 11, 2017
• Last updated: January 18, 2017
• Start date: January 2010
• Est. completion date: February 2014

Study information

• Verified date: January 2017
• Source: Poznan University of Medical Sciences
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this study was to verify the effect of 12-week with β-hydroxy-β-methylbutyrate (HMB) and a placebo (PLA) supplementation on body composition, anaerobic and aerobic capacity, as well as concentrations of the selected biochemical blood markers in trained athletes, in a randomised, double-blind, placebo-controlled crossover trial.

Description:

The effect of HMB supplementation is of great interest in sport. In view of the inconclusive character of the results of the studies conducted to date and of a relatively low number of studies investigating the effectiveness of HMB supplementation over a longer period on a large population of trained athletes, the aim of this study was to verify the effect of 12-week with HMB and a placebo supplementation on body composition, anaerobic and aerobic capacity, as well as concentrations of the selected biochemical blood markers in trained athletes, in a randomised, double-blind, placebo-controlled crossover trial.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 58
• Est. completion date: February 2014
• Est. primary completion date: February 2014
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Male
• Age group: 17 Years to 40 Years

Eligibility

Inclusion Criteria:

• written consent to participate,

• male

• a current medical clearance to practice sports,

• training experience: at least 5 years,

• minimum of 6 workout sessions a week (minimum 3 in the practiced sports discipline).

Exclusion Criteria:

• current injury,

• any health-related contraindication,

• declared general feeling of being unwell,

• unwilling to follow the study protocol.

Related Conditions & MeSH terms

• Sport
• Supplementation
• Supplements

Intervention

Dietary Supplement:
• ß-hydroxy-ß-methylbutyrate and a placebo supplementation

Locations

Country	Name	City	State
Poland	Poznan University of Life Sciences, ul.Wojska Polskiego 31	Poznan	Wielkopolska

Sponsors (3)

Lead Sponsor	Collaborator
Poznan University of Medical Sciences	National Science Centre, Poland, Poznan University of Life Sciences, Poznan, Poland

Country where clinical trial is conducted

Poland, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Changes of body composition indices after HMB supplementation	Analysis of the fat mass and fat free mass	Baseline and after 12 weeks
Primary	Changes of body composition indices after placebo treatment	Analysis of the fat mass and fat free mass	Baseline and after 12 weeks
Primary	Changes of aerobic capacity after HMB supplementation		Baseline and after 12 weeks
Primary	Changes of aerobic capacity after placebo treatment		Baseline and after 12 weeks
Primary	Changes of anaerobic capacity after HMB supplementation		Baseline and after 12 weeks
Primary	Changes of anaerobic capacity after placebo treatment		Baseline and after 12 weeks
Primary	Changes of creatine kinase and lactate dehydrogenase activity in blood after HMB supplementation		Baseline and after 12 weeks
Primary	Changes of creatine kinase and lactate dehydrogenase activity in blood after placebo treatment		Baseline and after 12 weeks
Primary	Changes of testosterone, cortisol and lactate levels in blood after HMB supplementation		Baseline and after 12 weeks
Primary	Changes of testosterone, cortisol and lactate levels in blood after placebo treatment		Baseline and after 12 weeks
Secondary	Statistical evaluation of the significance of differences between the changes in body composition (fat mass and fat free mass)		1 year
Secondary	Statistical evaluation of the significance of differences between the changes in aerobic capacity indices		1 year
Secondary	Statistical evaluation of the significance of differences between the changes in anaerobic capacity indices		1 year
Secondary	Statistical evaluation of the significance of differences between the changes in creatine kinase and lactate dehydrogenase activity and testosterone, cortisol and lactate levels in blood		1 year