Suicide, Attempted Clinical Trial
Official title:
Neuro Anatomic Basis of Psychic Pain in Depression and Suicidal Behaviour
Suicidal behaviour (SB) represents a major public health problem, costing life in more that one million people every year worldwide. Even if SB is considered as a consequence of social adversity and depression, these stress factors are often necessary but not sufficient to explain the occurrence of a suicidal act. A preliminary study suggests that an increased perception of psychic pain during a major depressive disorder increases the risk of suicide behaviour. The investigators aimed to investigate the relationship between social exclusion (a classic trigger of psychic pain) and SB and improve our knowledge about the physiopathology of this domain.
Status | Terminated |
Enrollment | 123 |
Est. completion date | December 2014 |
Est. primary completion date | August 2014 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Female |
Age group | 18 Years to 50 Years |
Eligibility |
Non specific criteria, for all the participants: - Woman- 18-50 years old - Non menopausal - Right-handed - Caucasian from western Europe (exception of Basque and Sardinian), for genetic purposes - Subject who signed informed consent - Able to understand the nature, the aim, and the methodology of the study and agree to cooperate during clinical and radiological evaluation Specific criteria:For depressed suicide attempters : - DSM IV criteria for major depressive disorder - Personal history of suicide attempt - No psychotropic treatment currently For depressed affective controls : - DSM IV criteria for major depressive disorder - No personal history of suicide attempt - No psychotropic treatment currently For non depressed suicide attempters : - Personal history of unipolar or bipolar mood disorder, according to DSM IV criteria - Normothymic currently (HAMD<7) - Personal history of suicide attempt - Minimum treatment Healthy controls : - No personal history of axis I psychiatric disorders according to the MINI and the DSM IV criteria |
Allocation: Non-Randomized, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Prevention
Country | Name | City | State |
---|---|---|---|
France | MontpellierUniversity Hopital | Montpellier |
Lead Sponsor | Collaborator |
---|---|
University Hospital, Montpellier | Institut National de la Santé Et de la Recherche Médicale, France, University Hospital, Geneva |
France,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Cerebral regions associated with psychic pain during a major depressive disorder | Magnetic Resonance Imaging to visualize cerebral regions associated with psychic pain during a major depressive disorder | One day | No |
Primary | Cerebral regions associated with perception of social exclusion | Magnetic Resonance Imaging to visualize the cerebral regions associated with perception of social exclusion | One day | No |
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