Subjective Cognitive Decline Clinical Trial
Official title:
The Efficacy and Neural Mechanism of Acupuncture Treatment in Older Adults With Subjective Cognitive Decline: a Randomized Controlled Trial
This study evaluates the efficacy and mechanism of acupuncture treatment in patients with subjective cognitive decline. Half of patients will receive acupuncture treatment for 12 weeks, while the other half will receive sham acupuncture treatment for 12 weeks .
Status | Recruiting |
Enrollment | 60 |
Est. completion date | March 2020 |
Est. primary completion date | January 2020 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 55 Years to 75 Years |
Eligibility |
Inclusion Criteria: 1. Male and female adults aged 55-75; 2. Native Chinese speakers with right-handed and at least a primary school education; 3. Self-reported persistent memory decline, which was confirmed by caregivers; 4. Normal general cognitive function and not meeting the criterion of mild cognitive impairment, as defined by performance within the normal range on both measures within at least one cognitive domain or in each of the three cognitive domains sampled (adjusted for age and education); 5. No or minimal impairment in activities of daily living; Exclusion Criteria: 1. Presence of positive neurologic history (e.g., traumatic brain injury, stroke, Parkinson's disease, multiple sclerosis, etc.) ; 2. treatments that would affect cognitive function; 3. Presence of significant psychiatric history (e.g., bipolar disorder, schizophrenia, etc.) and/or severe anxiety and depression; 4. Presence of serious heart, kidney, liver, gastrointestinal, infectious, endocrine disease or cancer; 5. History of alcohol or drug abuse/addiction in nearly two years; 6. Any contraindications for magnetic resonance imaging (MRI) scans (e.g., aneurysm clip pacemaker, etc.); 7. Significant visual and/or auditory impairment uncorrected by aids, and unable to perform neuropsychological evaluations; 8. Currently enrolled in another research study; 9. Received acupuncture treatment in the preceding month. |
Country | Name | City | State |
---|---|---|---|
China | School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine | Beijing | Beijing |
Lead Sponsor | Collaborator |
---|---|
Beijing Hospital of Traditional Chinese Medicine |
China,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Other | The degree of complaint in cognitive decline | measured by Subjective Cognitive Decline Questionnaire. | baseline and 12 weeks | |
Other | The sleep quality | Measured by Pittsburgh Sleep Quality Index | baseline and 12 weeks | |
Other | The depressive symptoms | Measured by Geriatric depression scale | baseline and 12 weeks | |
Other | The face recognition ability and sense of direction | Measured by Face recognition questionnaire and Santa Barbara Sense of Direction scale | baseline and 12 weeks | |
Primary | Change in cognitive function | A composite score will be computed by averaging z-scores from Animal Fluency Test, Digit Symbol Substitution Test, Trail-Making Test Parts A and B, Stroop Color Word Test C, Digit Span Test, Boston Naming Test, Clock Drawing Test and Auditory Verbal Learning Test delayed recall and delayed recognition. | Changes from baseline at 12 weeks | |
Secondary | Neuroplasticity outcome | Neuroplasticity outcome changes are measured by structural MRI (including DTI), task functional MRI, resting state functional MRI and arterial spin labeling. | baseline and 12 weeks |
Status | Clinical Trial | Phase | |
---|---|---|---|
Active, not recruiting |
NCT04121728 -
Modulation of Attention in Event Related Potential (ERPs) as a Marker of Early Cognitive Decline by Ginkgo Biloba
|
N/A | |
Active, not recruiting |
NCT03271190 -
Impact of a Cognitive Intervention Enriched With Leisure Activities in Persons With Subjective Cognitive Decline
|
N/A | |
Recruiting |
NCT06078748 -
The Lifestyle Exercise and Diet Trial (LEAD) 2.0
|
N/A | |
Recruiting |
NCT06287489 -
Effects of Mediterranean Diet on Subjective Cognitive Decline
|
N/A | |
Recruiting |
NCT05331144 -
Impact of Intensive Treatment of SBP on Brain Perfusion, Amyloid, and Tau (IPAT Study)
|
Phase 2 | |
Completed |
NCT02969460 -
Neurotrack Virtual Cognitive Health Study
|
N/A | |
Completed |
NCT03495037 -
Preventing Cognitive and Functional Decline Among Seniors at Risk
|
N/A | |
Recruiting |
NCT06095063 -
dTMS for Subjective Cognitive Decline
|
N/A | |
Recruiting |
NCT06110858 -
Efficacy of Tinkering Activities in Individuals With Subjective Cognitive Decline
|
N/A | |
Active, not recruiting |
NCT04330404 -
Effects of Cognitive Strategy Training on Daily Function in People With Subjective Cognitive Decline
|
N/A | |
Enrolling by invitation |
NCT03772977 -
The Brain Health Champion Study
|
N/A | |
Completed |
NCT03236454 -
tDCS-enhanced Working Memory Training in Subjective Cognitive Decline
|
N/A | |
Not yet recruiting |
NCT06358404 -
Developing a Peer Support Intervention for Depression in SCD
|
N/A | |
Completed |
NCT04796415 -
DEMA-Pro Intervention for Seniors With Subjective Cognitive Decline and Living at Home
|
N/A | |
Completed |
NCT04439500 -
Effects of Online Training Aimed at Increasing Participation in Everyday Life During a Pandemic (SCD Online).
|
N/A | |
Completed |
NCT04265378 -
Cognitive Training and Brain Stimulation in Prodromal Alzheimer's Disease
|
N/A | |
Completed |
NCT04880252 -
Neuropsychological Indicators of SCD Progression
|
||
Completed |
NCT03370744 -
Prediction of Cognitive Decline by Neuroimaging Techniques and the Application in Diagnosis and Treatment of Preclinical AD
|
||
Recruiting |
NCT06335836 -
The Effects of Social Isolation and Social Interaction on the Risk of Dementia Progression and Brain Function in SCD (Subjective Cognitive Decline, SCD)
|
||
Not yet recruiting |
NCT05225181 -
Effects of the Combining Physical Exercise and Cognitive Training for the Community-based Elderly
|
N/A |