Subfertility Clinical Trial
Official title:
Corifollitropin Alfa Compared to Daily Rec FSH in Poor Responders Undergoing ICSI Using a GnRH Antagonist Protocol
Corifollitropin alfa has been shown to result in significantly more oocytes compared to
daily recombinant follicle stimulating hormone (recFSH) (Devroey et al., 2009), probably due
to the higher circulating FSH activity during the first days of stimulation. For this
reason, the use of corifollitropin alfa might be beneficial in poor responders in whom the
number of oocytes retrieved is crucial for success.
The purpose of this study is to evaluate the effectiveness of corifollitropin alfa treatment
compared to daily recFSH in terms of the number of oocytes retrieved in a defined population
of poor responder patients undergoing intracytoplasmic sperm injection (ICSI) using
gonadotrophin releasing hormone (GnRH) antagonists.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment
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