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NCT00438373 Clinical Trial

LH/HCG Receptor Expression and Retrieval Rates

Subfertility Clinical Trial

Official title:
Association of LH/HCG Receptor Expression and Retrieval Rates at Oocyte Pick up.

Clinical Trial Details — Status: Suspended

Administrative data
NCT number NCT00438373
Other study ID # UHR-1
Secondary ID
Status Suspended
Phase N/A
First received February 21, 2007
Last updated February 25, 2015
Start date January 2007
Est. completion date January 2016

Study information
Verified date February 2015
Source Aristotle University Of Thessaloniki
Contact n/a
Is FDA regulated No
Health authority Greece: Ministry of Health and Welfare
Study type Observational

Clinical Trial Summary

The purpose of this study is to evaluate if there is an association between the serum LH receptor expression on the day of hCG administration or the day of oocyte retrieval and the retrieval rates at oocyte pick up

Description:

The purpose of this study is to evaluate if there is an association between the serum LH receptor expression on the day of hCG or the day of oocyte retrieval and the retrieval rates at oocyte pick up.

For this purpose, m-RNA copy numbers will be assessed in the blood serum of patients undergoing ovarian stimulation for IVF on different days.

Furthermore, detailed ultrasound scans will be perfomed, as well as assesment of hormonal levels during ovarian stimulation.

Recruitment information / eligibility
Status Suspended
Enrollment 100
Est. completion date January 2016
Est. primary completion date January 2016
Accepts healthy volunteers No
Gender Female
Age group 18 Years to 39 Years
Eligibility Inclusion criteria:

- Age <39 years,

- Body mass index (BMI) between 18 and 29 kg/m2,

- Presence of both ovaries,

- FSH levels <10 IU/l.

Exclusion criteria:

- Endometriomas,

- Polycystic ovarian syndrome.

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

Locations
Country Name City State
Greece Unit of Human Reproduction, 1st Department of Obstetrics & Gynecology, AUTH, Papageorgiou Hospital Thessaloniki

Sponsors (2)
Lead Sponsor Collaborator
Aristotle University Of Thessaloniki University of Athens

Country where clinical trial is conducted

Greece, 

References & Publications (2)

Patsoula E, Loutradis D, Drakakis P, Kallianidis K, Bletsa R, Michalas S. Expression of mRNA for the LH and FSH receptors in mouse oocytes and preimplantation embryos. Reproduction. 2001 Mar;121(3):455-61. — View Citation

Patsoula E, Loutradis D, Drakakis P, Michalas L, Bletsa R, Michalas S. Messenger RNA expression for the follicle-stimulating hormone receptor and luteinizing hormone receptor in human oocytes and preimplantation-stage embryos. Fertil Steril. 2003 May;79(5):1187-93. — View Citation

Outcome
Type Measure Description Time frame Safety issue
Primary LH/hCG receptor expression at oocyte retrieval No
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