Subarachnoid Hemorrhage Clinical Trial
Official title:
The Effects of Dexmedetomidine on Cerebral Autoregulation and Cerebral Oxygenation in Subarachnoid Haemorrhage Patients
The purpose of this study is to investigate how dexmedetomidine affects static and dynamic autoregulation, intracranial pressure (ICP) and cerebral oxygenation in aneurysmal subarachnoid haemorrhage (SAH) patients.
Dexmedetomidine is a selective α2-agonist which induces sedation, anxiolysis and analgesia
without respiratory depression. These effects, as well as neuroprotective properties in
experimental studies would be ideal in neuroanaesthesia and in neurocritical care. Poor
grade SAH patients are treated in intensive care units (ICU). These patients are sedated
often with propofol. However, to assess the patient's neurology, the propofol sedation must
be stopped and the wakening of the patient may take time. Dexmedetomidine would be more
advantageous, allowing wakening during the infusion. However, the effects of dexmedetomidine
on cerebral autoregulation are unknown in SAH patients.
15 SAH patients requiring sedation, mechanical ventilation and ICP monitoring will be rolled
in to the study.
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