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Stuttering clinical trials

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NCT ID: NCT05472181 Recruiting - Stuttering, Adult Clinical Trials

The Effects of Brain Stimulation on Speech Fluency in Adults Who Stutter

Start date: October 1, 2022
Phase: N/A
Study type: Interventional

The project is leading to investigate the effects of neuromodulation techniques on speech fluency among adults who stutter (AWS). While stuttering is responsive to a variety of treatments in childhood, this is not the case for AWS. Behavioural treatments to reduce stuttering for adults typically consist of speech restructuring methods, which involves the person using one of the altered speech patterns known to increase fluency, such as chorus reading, speaking in rhythm, and prolonging (smoothing/stretching out) speech sounds. Research has shown that behavioural interventions such as these change brain activation patterns in the regions associated with stuttering. Unfortunately, around 70% of AWS who receive these speech restructuring treatments do not maintain the benefits in the longer term and frequently re-present to speech clinics. The aim of this proposed research is to explore whether the brain stimulation using repetitive transcranial magnetic stimulation (rTMS) can consistently enhance effects of behavioural stuttering therapy by examining their responsiveness to the treatment across different outcome measures including a) immediate effect on different speaking contexts, and b) the maintenance of effects over one week after therapy.

NCT ID: NCT05437627 Not yet recruiting - Stuttering Clinical Trials

Computerized Based Analysis for Detection and Severity Assessment of Stuttering

Start date: September 1, 2022
Phase:
Study type: Observational [Patient Registry]

In the light of previous attempts to design and develop automated and objective measures for automatic speech recognition system that detects disfluent speech and assess its severity, yet fully automated measurement of stuttered speech is not available. This study was triggered by the need to design and develop a simple and reliable computerized tool for identification of stuttering and measurement for its severity. Therefore, the aim of this study is to develop a user interface that can work on windows system for the adopted stuttering recognition model which can be used in clinical practice by physicians and therapists.

NCT ID: NCT05437159 Not yet recruiting - Clinical trials for Stuttering, Developmental

Investigating Speech Sequencing in Neurotypical Speakers and Persons With Disordered Speech

Start date: March 2023
Phase: N/A
Study type: Interventional

Persistent developmental stuttering affects more than three million people in the United States, and it can have profound adverse effects on quality of life. Despite its prevalence and negative impact, stuttering has resisted explanation and effective treatment, due in large part to a poor understanding of the neural processing impairments underlying the disorder. The overall goal of this study is to improve understanding of the brain mechanisms involved in speech motor planning and how these are disrupted in neurogenic speech disorders, like stuttering. The investigators will do this through an integrated combination of experiments that involve speech production, functional MRI, and non-invasive brain stimulation. The study is designed to test hypotheses regarding the brain processes involved in learning and initiating new speech sound sequences and how those processes compare in persons with persistent developmental stuttering and those with typical speech development. These processes will be studied in both adults and children. Additionally, these processes will be investigated in patients with neurodegenerative speech disorders (primary progressive aphasia) to further inform the investigators understanding of the neural mechanisms that support speech motor sequence learning. Together these experiments will result in an improved account of the brain mechanisms underlying speech production in fluent speakers and individuals who stutter, thereby paving the way for the development of new therapies and technologies for addressing this disorder.

NCT ID: NCT05383430 Not yet recruiting - Clinical trials for ADHD Children With Stuttering

Prevalence of Stuttering in Children With ADHD at Sohag University Hospital

Start date: June 2022
Phase:
Study type: Observational

The majority of the latest research suggests that stuttering is associated with significantly elevated levels of trait and social anxiety. The prevalence of children who stutter and have attention deficit/ hyperactivity disorder (ADHD) ranges from 4 to 26%. About 10-20% of children who stutter might show ADHD. Gender ( male) is the dominant risk factor for stuttering, as also applies to other neurodevelopmental disorders. Examples include attention deficit hyperactive disorder (ADHD), conduct disorder, tics and the Gilles de la Tourette syndrome (GTS). These neurodevelopmental disorders are the second -most prominent set of comorbidities with stuttering. Attention-deficit hyperactivity disorder (ADHD) and stuttering share many characteristics in addition to temperament . A complex interplay of neural differences, with genetic and environmental components, has been reported as a possible cause of both disorders. In addition, both may appear more frequently in boys than in girls . Furthermore, it is emphasized that childhood stuttering can be accompanied by aspects of ADHD . Likewise, children exhibiting signs of ADHD more frequently display speech disfluencies than their peers. It is suggested that children with stuttering and those without stuttering will display different profiles in terms of temperament, certain aspects of ADHD, and some types of anxiety. In addition, it is to be expected that there will be some correlations between these variables in children who stutter. However, it is not possible to draw definite conclusions about this issue that could be generalized to all children who stutter. Furthermore, there are very few studies that deal with combinations of these variables .

NCT ID: NCT05339906 Recruiting - Stuttering, Adult Clinical Trials

Study of the Effect of the Auditory Stimulation on Stuttering Symptoms in Patients With a Deficit of Spectral Power in the EEG Beta Frequency Band

ZOV
Start date: May 25, 2021
Phase: N/A
Study type: Interventional

In this study, the investigators will research the efficacy of a novel auditory neuro modulating technology that leverages euphonic music tracks with broad-spectrum binaural beats to induce selective EEG spectral power changes.

NCT ID: NCT05306782 Recruiting - Stuttering Clinical Trials

Shaping Motor Neural Functioning of Developmental Stuttering to Improve Fluency

Start date: April 2, 2022
Phase: N/A
Study type: Interventional

Developmental stuttering (DS) is a motor/speech disorder, characterized by specific alterations in the functioning of brain circuits. Non-invasive brain stimulation may be useful to shape the altered functioning and connectivity of these systems. As a consequence, this project aims to expand the neurophysiological understanding of DS, evaluating effects of transcranial electrical stimulation (tES) on speech fluency and brain functioning of adults with persistent DS. This project will provide high-impact insights into the functioning of DS neural system, also proposing innovative and/or personalized rehabilitation.

NCT ID: NCT05291572 Not yet recruiting - Clinical trials for Stuttering, Childhood

Comparative Study Between Three Different Methods for Stuttering Therapy in Children

Start date: April 2022
Phase: Phase 4
Study type: Interventional

The aim of work is comparing between three different methods for treatment of stuttering in children in order to reach to the best method for treatment

NCT ID: NCT05286151 Recruiting - Stuttering Clinical Trials

Network Connectivity and Temporal Processing in Adolescents Who Stutter

Start date: July 23, 2022
Phase: N/A
Study type: Interventional

The specific purpose of this clinical trial is to compare performance on rhythm perception and production tasks between children who stutter and children who do not stutter. The overall project also aims to investigate how performance on rhythm tasks may be related to brain activity (non-clinical trial).

NCT ID: NCT05185726 Recruiting - Clinical trials for Stuttering, Developmental

TreatPaCS = Treatment for Preschool Age Children Who Stutter

TreatPaCS
Start date: April 1, 2022
Phase: N/A
Study type: Interventional

Treatment for preschool age children who stutter: a randomised, multicentre, non-inferiority parallel group pragmatic trial with Mini-KIDS, the social cognitive behaviour therapy and the Lidcombe Program with 249 children

NCT ID: NCT05003583 Recruiting - Clinical trials for Stuttering, Childhood

Effects of Emotional Processes on Speech Motor Control in Early Childhood Stuttering.

Start date: May 21, 2021
Phase: N/A
Study type: Interventional

This study will compare speech variability between preschool-age children who stutter and typically fluent, age-matched peers. Differences in emotional reactivity, regulation and speech motor control have been implicated in stuttering development in children. This study seeks to understand further how these processes interact. Children will repeat a simple phrase after viewing age-appropriate images of either negative or neutral valence to assess speech motor control.