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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT06047158
Other study ID # RCEOFOITP
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date December 1, 2022
Est. completion date December 1, 2023

Study information

Verified date September 2023
Source The Affiliated Hospital of Qingdao University
Contact Liu Ruiqing, Doctor
Phone 18661809036
Email liuruiqing@smail.nju.edu.cn
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The purpose of this study was to investigate the effects of omega-3 fish oil fat emulsion on peripheral blood C-reactive protein, total lymphocyte count, plasma albumin and immune function after radical surgery combined with intraperitoneal hyperthermic perfusion chemotherapy in patients with locally advanced gastric cancer. at the same time, to explore the effects of omega-3 fish oil fat emulsion on complications, length of stay and total cost of hospitalization. The main question it aims to answer is whether the use of omega-3 fish oil fat emulsion can improve patients' immunity, speed up recovery and reduce costs. Participants will comprehensively collect patient-related baseline data, including sex, age, BMI, ASA grade, tumor location, histological grade, pathological tumor type, pTNM stage (AJCC cancer stage 8), and perilymphatic vascular / nerve infiltration. Immune function evaluation related index: peripheral blood lymphocyte count. Plasma albumin concentration, C-reactive protein, postoperative infectious complications, length of stay and cost of hospitalization. Finally, statistical analysis software was used to analyze the differences between the two groups, evaluate the above indicators and draw mutual conclusions.


Description:

The research process is as follows: 1. Select patients in the group according to the inclusion and exclusion criteria. 2. The patient signed the informed consent form 3. His system was used to collect patient data, including human-related baseline data, including sex, age, BMI, ASA grade, tumor location, histological grade, pathological tumor type, pTNM stage (AJCC cancer stage 8th edition), lymphatic vascular / nerve infiltration. Immune function evaluation related index: peripheral blood lymphocyte count. Plasma albumin concentration, C-reactive protein, postoperative infectious complications, length of stay and cost of hospitalization. 4. Using statistical software (SPSS) to judge the statistical difference. 5. It is concluded that the use value of omega-3 fish oil fat emulsion (Ewing) is evaluated.


Recruitment information / eligibility

Status Recruiting
Enrollment 200
Est. completion date December 1, 2023
Est. primary completion date December 1, 2023
Accepts healthy volunteers No
Gender All
Age group 18 Years to 75 Years
Eligibility Inclusion Criteria: - The age is 18 to 75 years old. - For advanced gastric cancer, according to the TNM staging specified by the 8th edition AJCC, the clinical staging or EUS staging is above T2. There is no distant metastasis before operation, and the tumor does not directly invade the surrounding organs (liver, pancreas, spleen and transverse mesocolon, etc.). - There is no obvious contraindication to surgery. - The preoperative physical status score of Eastern American Cancer Cooperation (ECOG) was 0 or 1. - The preoperative ASA grade was grade ?-?. - No previous history of gastric surgery, no history of other malignant tumors. - After explaining the nature and purpose of the study, agree to sign an informed consent form, give voluntary consent to participate in the study, and comply with the requirements of the study. Exclusion Criteria: - Radiotherapy or chemotherapy before operation. - Use of immunosuppressants such as hormones within 3 months before treatment. - Preoperative anemia (hemoglobin < 90g/L) and severe hypoalbuminemia (albumin < 30g/L). - With severe heart and lung and other important organ dysfunction. - More serious metabolic and immune diseases, such as hyperthyroidism, poor blood glucose control in diabetes, obesity, hyperlipidemia (triglyceride > 3mmol/L, total bile solid > 6.2mmol/L). - Severe infection before operation. - With complete intestinal obstruction, intestinal perforation and intestinal necrosis. - During the operation, it was found that radical operation could not be performed or combined organ resection was needed. - Operation time > 6 hours, intraoperative bleeding > 400ml

Study Design


Intervention

Drug:
Omega-3 fish oil fat emulsion
Use omega-3 fish oil fat emulsion

Locations

Country Name City State
China Ruiqing Liu Qingdao Shan Dong

Sponsors (1)

Lead Sponsor Collaborator
The Affiliated Hospital of Qingdao University

Country where clinical trial is conducted

China, 

Outcome

Type Measure Description Time frame Safety issue
Primary Immune related index Peripheral blood lymphocyte count one week
Primary Immune related index Plasma albumin concentration one week
Primary Immune related index C-reactive protein concentration one week
Primary Immune related index Postoperative infectious complications one week
Secondary Hospitalization related Hospitalization time From the first day after operation to discharge, up to 30 days.
Secondary Hospitalization related Hospitalization expenses From the first day after operation to discharge, up to 30 days.
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