Prophylactic or Preemptive Entecavir in Patients With Gastric Cancer Who Are Inactive Hepatitis B Carriers

Stomach Neoplasms Clinical Trial

Official title: An Open, Randomized Controlled Clinical Trial to Compare the Prophylactic Use or Preemptive Use of an Anti-viral Drug Entecavir in Patients With Gastric Cancer Who Are Inactive Hepatitis B Carriers

Status Recruiting

Clinical Trial Summary

There has been no report on whether the patients with gastric cancer who are also inactive Hepatitis B carriers should receive prophylactic use or preemptive Use of an Anti-viral Drug Entecavir. This open, randomized controlled clinical trial aims to compare the impact of the prophylactic use or preemptive use of an anti-viral drug Entecavir on the outcomes of patients with gastric cancer who are also inactive hepatitis B carriers during chemotherapy and the subsequent follow-ups.

Clinical Trial Description

Patients with gastric cancer who are also inactive hepatitis B carriers are enrolled and randomized into two groups as following. Patients in experimental group are treated with entecavir prophylactically in the dose of 0.5mg p.o. every day from the initiation of chemotherapy till 6 months after the end of chemotherapy.Patients in active comparator group are only treated with entecavir in the dose of 0.5mg p.o. every day from the time that the DNA copies of hepatitis B virus are more than 100 IU/ml till 6 months after the end of chemotherapy. ;

Related Conditions & MeSH terms

• Hepatitis
• Hepatitis B
• Stomach Neoplasms

• NCT number: NCT02777801
• Study type: Interventional
• Source: Sun Yat-sen University
• Contact: Rui-hua Xu, PHD,MD
• Phone: +86 13922206676
• Email: xurh@sysucc.org.cn
• Status: Recruiting
• Phase: Phase 2
• Start date: June 2015
• Completion date: June 2018