Stomach Neoplasms Clinical Trial
Official title:
The Expression of Zinc Finger E-Box Binding Homeobox 1 (ZEB1) in Circulating Tumor Cells(CTCs) Associated With Metastasis and Recurrence for Gastric Cancer
The aim of this study was to investigate the expression of ZEB1 in CTCs for gastric cancer, its correlation with the clinicopathology of gastric cancer, and the role of ZEB1 in invasion and metastasis in gastric cancer.
Invasion and metastasis of tumors and postoperative recurrence are the main causes of death
in patients with gastric cancer and are also the key factors affecting the clinical
treatment and prognosis.
In this study, the investigators will detect the expression of ZEB1 in different types of
CTCs(epithelial,mesenchymal and mixed phenotype) for gastric cancer by CanPatrolTM2
detection technology.Our investigation of the relationship between ZEB1 and the occurrence
and development as well as the invasion and metastasis of gastric cancer is expected to
provide data for the prognosis and targeted therapy of gastric cancer.
Approximate 100 consecutive patients with gastric cancer and CTCs(+) will be enrolled in
this study.Detection of ZEB1 expression in CTCs at baseline will show the relationship
between ZEB1 and clinicopathological variables. Postoperative follow-up of ZEB1 expression
in CTCs will be performed every three months in the first year and every six months in the
following two years. The results may indicate the role of ZEB1 in CTCs about invasion and
metastasis for gastric cancer .The aim of this study is to clarify the clinical significance
of ZEB1 expression in CTCs for gastric cancer.
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Observational Model: Cohort, Time Perspective: Prospective
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