Stomach Neoplasms Clinical Trial
Official title:
Multicenter Study on Comparison of Long-term Outcome Between Laparoscopic and Open Distal Subtotal Gastrectomy With D2 Lymphadenectomy for Locally Advanced Gastric Cancer
- Laparoscopic distal subtotal gastrectomy with lymph node dissection as minimally
invasive surgery has gained popularity for the treatment of early gastric cancer in
East Asian countries, even though the long-term follow-up outcome based on multicenter
randomized clinical trial (RCT) is still awaited.
- For the patient with locally advanced gastric cancer, several studies indicated that
laparoscopic distal subtotal gastrectomy with D2 lymphadenectomy is a technically
feasible and safe procedure by experienced surgeons in high-volume specialized
hospitals. However, the application of it is controversial mainly due to lack of solid
evidence on the oncologic efficacy. Therefore, conventional open approach is still the
current standard for advanced gastric cancer.
- Nowadays, the proportion of patients with locally advanced gastric cancer is estimated
up to 80 per cent of all gastric cancer cases in China. Before the clinical application
of laparoscopic procedure for the treatment with curative intent to advanced gastric
cancer located at the middle- or lower-third of the stomach, the oncologic efficacy
must be verified.
- Accordingly,the comparison of intraoperative and postoperative complications between
laparoscopic and open distal subtotal gastrectomy for over 65 years old patients with
gastric cancer based on a randomized controlled trial is needed.
n/a
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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