Stomach Neoplasm Clinical Trial
Official title:
Phase II Study of S-1 in Combination With Oxaliplatin and Irinotecan in Patients With Advanced, Recurrent or Metastatic Gastric Cancer
This study will conduct a phase II study of triple combination with oxaliplatin, irinotecan, and S-1 as the first-line chemotherapy in patients with advanced gastric cancer.
It is widely accepted that the efficacy of chemotherapy for patients with inoperable,
advanced, and metastatic gastric cancer is better than that compared to best supportive care.
In general, combination chemotherapies are more efficient than monotherapy and so it is
reasonable to give combination chemotherapy to patients with good performance status.
Especially dual combination chemotherapy with fluoropyrimidine and platinum has shown the
objective response rate of 25-48% in patients with newly diagnosed advanced metastatic
gastric cancer and several studies about triple combination with oxaliplatin, irinotecan, and
fluoropyrimidine have shown the response rate of 53~75% but also higher rate of hematologic
adverse events. So the investigators had conducted the phase I study of these three drugs
with modification of dosage and schedule and will conduct a phase II study with recommended
dose of triple chemotherapy from this phase I study.
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