Ultra Structure Of Peritoneum At Electronic Microscopy In Control Subjects And Patients With Gastric Cancer

Stomach Neoplasm Clinical Trial

Official title:

Ultra Structure of Peritoneum at Electronic Microscopy in Control Subjects and Patients With Gastric Cancer

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00935779
• Other study ID #: OAIC 043/02
• Status: Completed
• Phase: N/A
• First received: July 7, 2009
• Last updated: July 8, 2009
• Start date: October 2002
• Est. completion date: December 2004

Study information

• Verified date: July 2009
• Source: University of Chile
• Contact: n/a
• Is FDA regulated: No
• Health authority: Chile: Instituto de Salud Pública de Chile
• Study type: Observational

Clinical Trial Summary

Peritoneal metastases appear in a great proportion of patients affected by gastric carcinoma. Involved mechanisms are poorly understood though experimentally it has been demonstrated that neoplastic cells exfoliated from primary tumor can only implant and proliferate in areas of damaged peritoneum. Objectives: to study ultra-structure of peritoneal surface by electronic microscopy in control subjects and in patients with early or locally advanced gastric cancer looking for spontaneous changes in peritoneal surface not related with surgical injury.

Description:

18 out of 32 cases were eligible for analysis. Four patients operated on for benign diseases served as control and 14 patients with operable local gastric adenocarcinoma (4 mucosa/submucosa/muscular y 10 serosa lesions) were studied. At the beginning of surgery, a 2 x 2 cm. sample from macroscopically normal visceral peritoneum at mesenterium root was carefully obtained, washed with saline and fixed in glutaraldehyde solution. Besides a sample of peritoneal washing fluid was studied to exclude patients with free cancer cells. Peritoneal tissue was fixed during 24 hours and then all samples were evaluated by electronic microscope.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 18
• Est. completion date: December 2004
• Est. primary completion date: July 2004
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• patients with operable local gastric adenocarcinoma

Exclusion Criteria:

• previous abdominal surgery

• previous open or blunt abdominal trauma

• history of inflammatory bowel disease or Typhoid Fever, Gallstone disease, chemotherapy or radiotherapy, or any other abdominal condition that could alter peritoneal integrity.

• All other gastric malignancies such as lymphomas, GIST, carcinoids

Study Design

Observational Model: Case Control, Time Perspective: Prospective

Related Conditions & MeSH terms

• Stomach Neoplasm
• Stomach Neoplasms

Locations

Country	Name	City	State
Chile	Department of Surgery, Clinical Hospital, University of Chile	Santiago	Region Metropolitana

Sponsors (1)

Lead Sponsor	Collaborator
University of Chile

Country where clinical trial is conducted

Chile,