Stem Cells Clinical Trial
Official title:
The Acute Effect of a Theacrine-based Supplement on Mobilization of Various Stem Cell Populations.
NCT number | NCT06219161 |
Other study ID # | U0001 |
Secondary ID | |
Status | Completed |
Phase | N/A |
First received | |
Last updated | |
Start date | January 2, 2023 |
Est. completion date | July 31, 2023 |
Verified date | January 2024 |
Source | University of Memphis |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
The goal of the study is to determine the acute and short-term supplementation effect of a commercially available theacrine-containing supplement (NAD3) on numbers of various circulating stem cell populations in older adults.
Status | Completed |
Enrollment | 12 |
Est. completion date | July 31, 2023 |
Est. primary completion date | June 30, 2023 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 40 Years to 70 Years |
Eligibility | Inclusion Criteria: - Male or Female - Age 40-70 - BMI between 21-34.99 kg/m2 - Vital signs with in normal range (heart rate 60-100 beats/minute, blood pressure (40-44 years - 125/83, 45-49 years- 127/84, 50-54 years -129/85, 55-59 years - 131/86, >60 - 134/87), 36.4-37.4 degrees Celsius - Sedentary to lightly active (2 or fewer days per week of exercise) Exclusion Criteria: - Female participants who are lactating, pregnant or planning to become pregnant during the study - History of use of illicit drugs or other substances of abuse within 12 months of the screening visit (to be determined at screening) - Tobacco during the 90 days prior to screening - Current use of medication/dietary supplements that claim to or have an effect on age-related processes, e.g. "anti-aging" supplements. Participants must undergo a =7-day washout period of no supplementation to be eligible. - Known allergy, intolerance or hypersensitivity to NAD3 - Self-reported active infection or illness of any kind - Cognitively impaired and/or unable to give informed consent |
Country | Name | City | State |
---|---|---|---|
United States | The University of Memphis | Memphis | Tennessee |
Lead Sponsor | Collaborator |
---|---|
University of Memphis | Compound Solutions Inc. |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change of stem cell numbers in blood circulation. | Flow cytometry evaluation of stem cell phenotype. | Changes at 1 and 2 hours after consumption of study product. | |
Secondary | Change to numbers of circulating HSC- CD45, CD34, CD133. | Flow cytometry evaluation of stem cell phenotype. | Changes at 1 and 2 hours after consumption of study product. | |
Secondary | Change to numbers of circulating CEC - CD45, CD31, CD309. | Flow cytometry evaluation of stem cell phenotype. | Changes at 1 and 2 hours after consumption of study product. | |
Secondary | Change to numbers of circulating MSC-CD45, CD31, CD90. | Flow cytometry evaluation of stem cell phenotype. | Changes at 1 and 2 hours after consumption of study product. |
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