Epidemiological Study of Intestinal Colonization With Staphylococcus Aureus

Staphylococcus Aureus Clinical Trial

— DigeSTAPH  

Official title:

Epidemiological Study of Intestinal Colonization With Staphylococcus Aureus in a Cohort of Adult Patients Hospitalized in Intensive Care at the University Hospital of St Etienne.

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02547272
• Other study ID #: 1208087
• Secondary ID: 2012-A01182-41
• Status: Completed
• Phase: N/A
• First received: September 9, 2015
• Last updated: March 22, 2016
• Start date: February 2013
• Est. completion date: July 2013

Study information

• Verified date: March 2016
• Source: Centre Hospitalier Universitaire de Saint Etienne
• Contact: n/a
• Is FDA regulated: No
• Health authority: France: Commission nationale de l'informatique et des libertésFrance: French Data Protection Authority
• Study type: Observational

Clinical Trial Summary

Nasal colonization with S. aureus is a risk factor for infection with this bacterium. A methodologically well conducted study of S. aureus bacteremia showed that 80% of S. aureus bacteremia with are due to the strain isolated in the nasal level. However, as part of a study coordinated by the CHU of Saint-Etienne, less than 50% of infections in prosthetic orthopedic devices have been linked to nasal carriage . Outside of exogenous infections, intestinal colonization with S. aureus could be an alternative source of endogenous infections with the waning of orthopedic surgery. In the general population, considering that about one third of the subjects were colonized with S. aureus nasal level and 1 in 5 in the intestine However the proportion of exclusive intestinal porting is not well known .

This study will analyze, among ICU patients, porting S. aureus nasal and rectal level. It will better clarify the relationship between nasal and rectal ports and the risk of developing an infection.

Description:

The adult patients hospitalized in intensive care at the University Hospital of Saint-Etienne have a multiresistant bacteria porting screening at the nose and rectum at admission and then once a week. These samples will be carried unchanged way for the study but will also be a research S Aureus

Recruitment information / eligibility

• Status: Completed
• Enrollment: 400
• Est. completion date: July 2013
• Est. primary completion date: July 2013
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• patients hospitalized in intensive care and benefiting from a screening multiresistant bacteria in nasal and rectal level under routine care

Exclusion Criteria:

• refusal of the patient's family

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

• Staphylococcus Aureus

Intervention

Procedure:
• Nasal and rectal bacterial samples
Bacterial nasal and rectal samples at admission and one weekly for the presence of S Aureus

Locations

Country	Name	City	State
France	CHU de Saint-Etienne	St Etienne

Sponsors (1)

Lead Sponsor	Collaborator
Centre Hospitalier Universitaire de Saint Etienne

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	prevalence of S. aureus colonization at rectal level	The presence of a colony of S. aureus on one of the samples	1 month	No
Secondary	S. aureus strains similar to nasal and rectal level	S. aureus strains similar in molecular typing	1 month	No