Stage IV Melanoma Clinical Trial
Official title:
FDG-PET/CT as a Biomarker for Treatment Response in Advanced Melanoma
This clinical trial studies how well FDG-PET/CT measures early response in patients with stage III-IV melanoma who are receiving chemotherapy. Positron emission tomography (PET)/computed tomography (CT) uses a metabolic imaging radiotracer, [18F]fluorodeoxyglucose (FDG), which selectively accumulates in tumors. FDG-PET/CT of advanced melanoma before, during, and after treatment may improve methods for predicting which patients may benefit from therapy.
PRIMARY OBJECTIVES:
I. To correlate treatment-induced changes in FDG uptake with changes in tumor size and
progression-free survival (PFS) in patients receiving therapy for advanced melanoma.
II. To correlate treatment-induced changes in FDG uptake with changes in the activity and/or
expression of available molecular biomarkers from patients receiving therapy for advanced
melanoma.
OUTLINE:
Patients undergo FDG-PET/CT up to 2 weeks prior to first dose of therapy, after completion
of the first treatment course (day 21), and after completion of the fourth treatment course
(day 84).
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