Stable Angina Pectoris Clinical Trial
Official title:
Comparison of Carvedilol and Atenolol on Anti-anginal and Metabolic Effects in Patients With Stable Angina Pectoris
Verified date | September 2015 |
Source | Gachon University Gil Medical Center |
Contact | n/a |
Is FDA regulated | No |
Health authority | Korea: Institutional Review Board |
Study type | Interventional |
There are few data regarding anti-anginal effects between beta-blockers with and without vasodilating property. Beta-blocker without vasodilating property is generally known to have unfavorable effects on glucose and lipid metabolism. Therefore, the investigators compared carvedilol and atenolol on anti-anginal and metabolic effects in patient with stable angina pectoris.
Status | Completed |
Enrollment | 99 |
Est. completion date | August 2013 |
Est. primary completion date | August 2013 |
Accepts healthy volunteers | No |
Gender | Both |
Age group | 20 Years to 80 Years |
Eligibility |
Inclusion Criteria: - Stable angina pectoris who had a positive exercise treadmill test according to the American College of Cardiology Foundation and the American Heart Association guidelines Exclusion Criteria: - Acute coronary syndrome - Coronary revascularization within the past 3 months - Asthma or chronic obstructive lung disease - Bradycardia (heart rate < 55 beat/min) - History of severe adverse reaction to beta-blockers - Symptomatic arrhythmia requiring anti-arrhythmia therapy - Heart failure - Severe renal or hepatic failure |
Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
Country | Name | City | State |
---|---|---|---|
Korea, Republic of | Gachon University Gil Medical Center | Incheon |
Lead Sponsor | Collaborator |
---|---|
Gachon University Gil Medical Center |
Korea, Republic of,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Time to 1-mm ST-segment depression | Time to 1-mm ST-segment depression at exercise treadmill test | After 25 weeks of treatment | No |
Primary | Time to onset of angina | Time to onset of angina at exercise treadmill test | After 25 weeks of treatment | No |
Secondary | Blood pressure at resting and peak exercise | Blood pressure at resting and peak exercise during exercise treadmill test | After 25 weeks of treatment | No |
Secondary | Heart rate at resting and peak exercise | Heart rate at resting and peak exercise during exercise treadmill test | After 25 weeks of treatment | No |
Secondary | Lipid profiles | Lipid profiles: total cholesterol, triglyceride, high-density lipoprotein-cholesterol, and low-density lipoprotein-cholesterol | After 25 weeks of treatment | No |
Secondary | Glucose metabolism | Fasting glucose, insulin, HbA1c, Quantitative Insulin-Sensitivity Check Index (QUICKI) | After 25 weeks of treatment | No |
Secondary | Seattle Angina Questionnaire (SAQ) scores | After 25 weeks of treatment | No | |
Secondary | Treatment-emergent adverse events | After 25 weeks of treatment | Yes |
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