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De-Escalation Therapy for Human Papillomavirus Negative Disease — DEPEND  

Squamous Cell Carcinoma Clinical Trial

Official title:
A Phase II Trial of Carboplatin, Paclitaxel, and Nivolumab Induction Therapy Followed by Response-stratified Locoregional Therapy for Patients With Locally Advanced, HPV-negative Head and Neck Cancer. The DEPEND Trial.

Clinical Trial Summary

This study is looking to see if nivolumab, an immunotherapy drug, given with carboplatin and paclitaxel (2 chemotherapy agents) during induction therapy in advanced stage HPV negative patients can significantly shrink the subject's cancer.

Clinical Trial Description

n/a

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03944915
Study type Interventional
Source University of Chicago
Contact Everett Vokes, MD
Phone 773-702-9306
Email evokes@medicine.bsd.uchicago.edu
Status Recruiting
Phase Phase 2
Start date August 26, 2019
Completion date July 1, 2024
View Details
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