Sports Nutritional Sciences Clinical Trial
Official title:
Opioid System Cerebral Activity in Endurance Sportswomen - Addiction or Denutrition ? [11C]Diprenorphine PET Study
Abnormal opioid system have been identified in addictive behavior and activity of the opioid
system has also shown a strong link with the nutritional balance. A significant increase in
endorphin levels was noticed after exercise, proportional to the duration and intensity of
this activity. One brain imaging study showed an increase in opioid activity in athletes
after endurance training. However , a decrease in opioid tone related to receptor
desensitization in the brain has been raised in the sport and it is possible to feel like ,
the subject must perform physical exercise more frequently . Consequently, in order to deepen
the hypothesis of addiction in high-level sport , the brain opioid activity should be
assessed pre- training compared to a group of sedentary control subjects .
Preliminary results of a previous study the investigators are conducting on anorexia nervosa
(AN ) show abnormalities that appear to be involved in self addiction anorexia nervosa and
the regulation of gonadal function. However, the relation of cause and effect between these
anomalies and undernutrition remains to be determined . Given the addictive component in the
endurance sport and the variability of the nutritional status of its practitioners ,
evaluation of brain activity in these subjects could provide additional answers.
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