Could Tai-chi Help Maintain Balance of Spinocerebellar Ataxia Patients

Spinocerebellar Ataxias Clinical Trial

Official title:

Integrative Medicine and Tai-chi in Clinical Status of Spinocerebellar Ataxia

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03687190
• Other study ID #: 121013
• Status: Completed
• Phase: N/A
• Start date: May 13, 2013
• Est. completion date: December 2, 2015

Study information

• Verified date: August 2023
• Source: Changhua Christian Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Spinocerebellar atrophy is the most common autosomal dominant inherited ataxia. There are over thirty subtypes, which characterize neurologic features differently. They all have obvious substantial cerebellar atrophies in image, and unstable gait、ataxia. In general a prevalence of about three cases per 100 000 people is assumed, but this may be an underestimate. Progressive neurologic degeneration, in about 10-20 years, will leads to disability or wheelchair-dependent. Accompanying with fatigue, downhill course of the disease often made patients depressive and hopeless. The recent review of researches concludes no effective therapy for the disease. The purpose of the investigator's study is to explore the Tai-chi exercise effect for spinocerebellar ataxia.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 21
• Est. completion date: December 2, 2015
• Est. primary completion date: December 2, 2015
• Accepts healthy volunteers: No
• Gender: All
• Age group: 20 Years to 80 Years

Eligibility

Inclusion Criteria:

• progressive ataxia accompanied with the observation of cerebellar atrophy on magnetic resonance or computed tomography images

• SARA score of less than 20

Exclusion Criteria:

• Patients with complicated cerebellar disorders, such as multiple system atrophy, Parkinson-plus syndromes, secondary cerebellar degeneration from encephalitis, trauma, hypoxia, cerebrovascular diseases, and toxic- or drug-induced cerebellar degeneration

• SARA score of larger than 20

Related Conditions & MeSH terms

• Ataxia
• Cerebellar Ataxia
• Spinocerebellar Ataxias
• Spinocerebellar Degenerations
• Tai Chi

Intervention

Behavioral:
• Tai chi
participants were required to receive hospital-based Tai chi training at least once a month, and home-based Tai chi exercise at least three times a week over the next 9 months

Drug:
• conventional medicine
participants without Tai chi training still received routine conventional medicine

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
Changhua Christian Hospital

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Scale for the Assessment and Rating of Ataxia(SARA)	SARA assesses eight aspects of cerebellar function: walking, sitting, standing, speaking, finger chasing, the nose-finger test, fast alternating hand movements, and the heel-shin slide. The eight categories accumulate score ranging from 0 (no ataxia) to 40 (most severe ataxia).Gait (0-8 points),Stance (0-6 points),Sitting (0-4 points),Speech disturbance (0-6 points),Finger chase (0-4 points),Nose-finger test (0-4 points),Fast alternating hand movement (0-4 points),Heel-shin slide (0-4 points)	assessed at baseline and 9 months, 9 months reported as Outcome Measure Data