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Screening for Systemic Amyloidosis Via the Ligamentum Flavum — ALF  

Spinal Stenosis Clinical Trial

Official title:
Screening for Systemic Amyloidosis Via the Ligamentum Flavum

Clinical Trial Summary

The investigators will prospectively evaluate for the presence of amyloid deposits in ligamentum flavum (yellow ligament) tissue samples obtained from patients undergoing spinal stenosis surgery. Patients who have tissue that stains positive for amyloid will be referred to an amyloidosis specialist.

Clinical Trial Description

Similar to carpal tunnel syndrome, spinal stenosis is associated with systemic amyloidosis and presents earlier than cardiac amyloidosis symptoms - 21-45% of ATTR patients and case reports in AL patients. The investigators' recent study found that 10% of older patients undergoing carpal tunnel release surgery were positive for amyloidosis, with 20% of that group presenting with cardiac involvement. 70% of the amyloid-positive group had a history of spinal stenosis and 40% required surgical intervention. Surgical intervention for spinal stenosis could provide an opportunity to screen for amyloidosis through yellow ligament (ligamentum flavum) biopsy. This study will look at the prevalence of amyloidosis in patients undergoing surgical intervention for non-congenital spinal stenosis and spondyloarthropathy. The investigators hypothesize that 10% of such patients will be positive for amyloidosis. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT03923920
Study type Observational
Source The Cleveland Clinic
Contact
Status Completed
Phase
Start date May 1, 2019
Completion date December 2, 2021
View Details
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