Does PTH 1-34 (Teriparatide) Enhance Spinal Fusion in Humans?

Status Completed

Clinical Trial Summary

Parathyroid (PTH) hormone has been shown to enhance fracture healing in animal studies. There are so far only three published papers concerning humans. Postero-lateral fusions have shown a healing rate of less than 50% after bone. The purpose of this study is to determine if PTH 1-34 (teriparatide) improves the healing rate and the clinical course after spinal stenosis surgery.

Clinical Trial Description

100 patients undergoing surgery due to spinal stenosis and intraoperatively treated with autologous bone graft, will be randomised to either 4 weeks of daily injections with teriparatide or control.

Primary outcome: The rate of healing at 6 months on CT Scans. Secondary outcomes; Pain (VAS), function (Oswestry Disability Index), quality of life (EQ-5D) at 3 and 6 months. ;

Study Design

Related Conditions & MeSH terms

Spinal Stenosis

Clinical Trial Details

NCT number	NCT02090244
Study type	Interventional
Source	University Hospital, Linkoeping
Contact
Status	Completed
Phase	Phase 4
Start date	August 2012
Completion date	January 1, 2019

View Details

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