Effects of 4-AP on Functional SCI Recovery

Status Recruiting

Clinical Trial Summary

The purpose of this study is to test a strategy to potentiate functional recovery of lower limb motor function in individuals with spinal cord injury (SCI). The FDA approved drug, Dalfampridine (4-AP). 4-AP will be used in combination of Spike-timing-dependent plasticity (STDP) stimulation and STDP stimulation with limb training.

Clinical Trial Description

Currently, research has shown that 4-AP has a positive effect on sensory and motor function rehabilitation in humans with chronic SCI in addition to decreasing recorded spasticity, increased sensation, and decreased pain. Utilizing limb training to promote recovery of motor function is enhanced by eliciting STDP in the limbs. An important strength of this aim is the combination of training and STDP, which aims at enhancing the beneficial effects of motor training by promoting plasticity in the corticospinal pathway. We hypothesize that introducing 4-AP into the STDP stimulation and STDP stimulation with lower-limb training will further improve motor function rehabilitation in patients with chronic SCI. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05447676
Study type	Interventional
Source	Shirley Ryan AbilityLab
Contact	Monica A Perez, PT, PhD
Phone	312-238-2886
Email	mperez04@sralab.org
Status	Recruiting
Phase	Early Phase 1
Start date	June 30, 2022
Completion date	June 30, 2025

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