Spinal Cord Injury Clinical Trial
Official title:
Symptom-Based Treatment for Neuropathic Pain in Spinal Cord Injured Patients, Randomized Clinical Trial
1. Neuropathic pain in spinal cord injured patients
1. Inclusion criteria
- pain intensity, visual analogue scale > 3
- a LANSS (Leeds assessment of neuropathic symptoms and signs) score of 12 and above
- aged ≥20
2. Method
- Stop pain medications
- Test oxcarbazepine (150mg twice daily) and pregabalin (150mg twice daily)
- Check pain intensity (VAS score) with Baron's classification
In the present study, pharmacologic treatment included pregabalin and oxcarbazepine.
Stop medications such as Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), tramadol and
anti-spastic drugs (baclofen, tizanidine) and other medications known to have effect on pain
and the central nervous system prior to the study for at least 3 days.
1. Pain intensity (VAS score)
1. 4 spontaneous characters
- electric
- burning
- pricking
- numbness
2. evoked pain
- allodynia
- heat hyperalgesia
- pressure hyperalgesia
2. Location of neuropathic pain
1. neuropathic pain at level of spinal cord injury
2. neuropathic pain below level of spinal cord injury
2. Side effects
;
Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
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