S-100B and Neuron-specific Enolase (NSE) in Spinal Trauma

Spinal Cord Injury Clinical Trial

— WBS  

Official title:

The Clinical Use of S-100B and NSE in Spinal Cord Injuries

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT00980434
• Other study ID #: Wolf-4
• Status: Completed
• Phase: N/A
• First received: September 18, 2009
• Last updated: April 3, 2012
• Start date: February 2008
• Est. completion date: December 2011

Study information

• Verified date: July 2011
• Source: Medical University of Vienna
• Contact: n/a
• Is FDA regulated: No
• Health authority: Austria : Federal Ministry for Labour, Health, and Social Affairs
• Study type: Observational

Clinical Trial Summary

The investigators are studying the clinical worth of the serum markers S-100B and NSE in patients with spinal cord injuries e.g. in patients with vertebral fractures. If there is a injury to the neuronal structures these two proteins could be secreted into the serum and add evidence to the severity of the injury.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 60
• Est. completion date: December 2011
• Est. primary completion date: November 2011
• Accepts healthy volunteers: No
• Gender: Both
• Age group: 1 Year and older

Eligibility

Inclusion Criteria:

• vertebral fracture

• injuries to the vertebral spine

Exclusion Criteria:

• head trauma

• polytrauma

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Related Conditions & MeSH terms

• Spinal Cord Injuries
• Spinal Cord Injury

Locations

Country	Name	City	State
Austria	Medical University of Vienna	Vienna

Sponsors (1)

Lead Sponsor	Collaborator
Medical University of Vienna

Country where clinical trial is conducted

Austria, 

References & Publications (4)

Loy DN, Kim JH, Xie M, Schmidt RE, Trinkaus K, Song SK. Diffusion tensor imaging predicts hyperacute spinal cord injury severity. J Neurotrauma. 2007 Jun;24(6):979-90. — View Citation

Marquardt G, Setzer M, Seifert V. Protein S-100b as serum marker for prediction of functional outcome in metastatic spinal cord compression. Acta Neurochir (Wien). 2004 May;146(5):449-52. Epub 2004 Mar 22. — View Citation

Marquardt G, Setzer M, Seifert V. Protein S-100b for individual prediction of functional outcome in spinal epidural empyema. Spine (Phila Pa 1976). 2004 Jan 1;29(1):59-62. — View Citation

Marquardt G, Setzer M, Seifert V. Serum biomarkers for experimental acute spinal cord injury: rapid elevation of neuron-specific enolase and S-100 beta. Neurosurgery. 2006 Mar;58(3):E590; author reply E590. — View Citation

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Neurological Symptoms		2 weeks	No