Spinal Cord Injury(SCI) Clinical Trial
Following injury to the spinal cord, the spinal circuit undergoes a series of adaptations.
In parallel with the spinal circuit adaptation, the muscular properties also adapt. In human
and animal studies, histochemical and physiological evidences showed that the paralyzed
muscle transferred from slow, fatigue-resistant to fast, fatigable after injury.
Reversal of neuromuscular property for persons with SCI needs to be resolved. Studies using
high load electrical stimulations showed a reverse change of muscular properties, such as
hypertrophy and reversal of fiber type transformations but failed to show a reversal of
spinal circuitry function. Previous studies found that fast continuous passive motion (CPM)
altered the H reflex excitability in human. Animal studies found that passive cycling and
passive stretching delayed atrophy and influenced the transition of type I and IIa MHC.
Theses findings lead to a hypothesis that mechanical stimulation might be able to reverse
both spinal circuitry and muscular properties after SCI but it has not been confirmed in
human study.
The purpose of this project is to investigate the effect of mechanical stimulation by fast
CPM on the reversing adaptation of human paralyzed muscle after SCI.
n/a
Allocation: Non-Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
| Status | Clinical Trial | Phase | |
|---|---|---|---|
| Completed |
NCT02122276 -
Effects of Continuous Passive Motion on the Spinal Circuitries and Its Adaptation in Patients With Spasticity Resulting From Upper Motor Neuron Lesions
|
N/A | |
| Completed |
NCT01988142 -
The Effect of Continuous Passive Motion Training on Neuromuscular Adaptation
|
N/A |