Impact of Peripheral Afferent Input on Central Neuropathic Pain

Status Not yet recruiting

Clinical Trial Summary

The overarching aim of this study is to investigate the contribution of peripheral afferent input to spontaneous and evoked central neuropathic pain after a spinal cord lesion or disease.

Clinical Trial Description

A key question that has been subject to longstanding debates in the field relates to the sites and mechanisms within the peripheral or central nervous system that potentially perpetuate chronic spontaneous and evoked central neuropathic pain. The investigators hypothesize that spontaneous central neuropathic pain depends on continuous, "physiological" somatosensory input from the painful body region in the periphery. Thus, spontaneous central neuropathic pain results from pathological gain control in central somatosensory networks with decreased activation thresholds for thermo- and mechanosensitive peripheral afferents. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05646810
Study type	Interventional
Source	University of Aarhus
Contact	Nanna B. Finnerup, Professor
Phone	0045 784 63380
Email	finnerup@clin.au.dk
Status	Not yet recruiting
Phase	N/A
Start date	December 1, 2022
Completion date	December 31, 2023

View Details

See also
Status	Clinical Trial	Phase
Active, not recruiting	`NCT06321172` - Muscle and Bone Changes After 6 Months of FES Cycling	N/A
Completed	`NCT03457714` - Guided Internet Delivered Cognitive-Behaviour Therapy for Persons With Spinal Cord Injury: A Feasibility Trial
Recruiting	`NCT05484557` - Prevention of Thromboembolism Using Apixaban vs Enoxaparin Following Spinal Cord Injury	N/A
Suspended	`NCT05542238` - The Effect of Acute Exercise on Cardiac Autonomic, Cerebrovascular, and Cognitive Function in Spinal Cord Injury	N/A
Recruiting	`NCT05503316` - The Roll of Balance Confidence in Gait Rehabilitation in Persons With a Lesion of the Central Nervous System	N/A
Not yet recruiting	`NCT05506657` - Early Intervention to Promote Return to Work for People With Spinal Cord Injury	N/A
Recruiting	`NCT04105114` - Transformation of Paralysis to Stepping	Early Phase 1
Recruiting	`NCT03680872` - Restoring Motor and Sensory Hand Function in Tetraplegia Using a Neural Bypass System	N/A
Completed	`NCT04221373` - Exoskeletal-Assisted Walking in SCI Acute Inpatient Rehabilitation	N/A
Completed	`NCT00116337` - Spinal Cord Stimulation to Restore Cough	N/A
Completed	`NCT03898700` - Coaching for Caregivers of Children With Spinal Cord Injury	N/A
Recruiting	`NCT04883463` - Neuromodulation to Improve Respiratory Function in Cervical Spinal Cord Injury	N/A
Active, not recruiting	`NCT04881565` - Losing Balance to Prevent Falls After Spinal Cord Injury (RBT+FES)	N/A
Completed	`NCT04864262` - Photovoice for Spinal Cord Injury to Prevent Falls	N/A
Recruiting	`NCT04007380` - Psychosocial, Cognitive, and Behavioral Consequences of Sleep-disordered Breathing After SCI	N/A
Active, not recruiting	`NCT04544761` - Resilience in Persons Following Spinal Cord Injury
Completed	`NCT03220451` - Use of Adhesive Elastic Taping for the Therapy of Medium/Severe Pressure Ulcers in Spinal Cord Injured Patients	N/A
Terminated	`NCT03170557` - Randomized Comparative Trial for Persistent Pain in Spinal Cord Injury: Acupuncture vs Aspecific Needle Skin Stimulation	N/A
Recruiting	`NCT04811235` - Optical Monitoring With Near-Infrared Spectroscopy for Spinal Cord Injury Trial	N/A
Recruiting	`NCT04736849` - Epidural and Dorsal Root Stimulation in Humans With Spinal Cord Injury	N/A