Neural Facilitation of Movements in People With SCI

Spinal Cord Injuries Clinical Trial

Official title: Neural Facilitation of Stimulation-assisted Movements in People With Spinal Cord Injury

Status Terminated

Clinical Trial Summary

Spinal cord injury leads to long-lasting paralysis and impairment. Re-enabling movement of paralyzed areas is challenging and more information is needed about neurological recovery. The purpose of this study is to understand the contribution of individual neural tracts to movements facilitated by transcutaneous spinal cord stimulation (SCS).

Clinical Trial Description

Spinal cord injury leads to long-lasting motor impairment and paralysis that currently is not "curable". Electrical spinal cord stimulation (SCS) is beginning to be used as a neuromodulation technique to re-enable movement of paralyzed areas, however the mechanisms of neurorecovery induced by electrical neuromodulation of the spinal cord remain poorly understood. The goal of this project is to generate evidence-based knowledge of changes in the short-term excitability of corticospinal and reticulospinal neural structures that may mediate immediate improvements in motor function enabled by SCS. The proposed study will: (1) determine which kinds of SCS-facilitated movements are mediated by the corticospinal tract. (2) determine which kinds of SCS-facilitated movements are mediated by the reticulospinal tract. Having a better understanding of the neural mechanisms that are enhanced by SCS can allow the development of therapies that directly target the excitability and plasticity states of these structures towards improved and accelerated recovery. ;

Related Conditions & MeSH terms

• Spinal Cord Injuries

• NCT number: NCT05354206
• Study type: Interventional
• Source: Washington University School of Medicine
• Status: Terminated
• Phase: N/A
• Start date: July 12, 2022
• Completion date: March 6, 2023