Spinal Cord Injuries Clinical Trial
Official title:
Improving Ventilatory Capacity in Those With Chronic High Level SCI
The purpose of this study is to find out if taking the drug Buspar will increase breathing capacity in individuals with spinal cord injuries.
Status | Recruiting |
Enrollment | 30 |
Est. completion date | November 29, 2024 |
Est. primary completion date | November 29, 2023 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 50 Years |
Eligibility | Inclusion Criteria: - Chronic high-level SCI (at least 24-months post injury) - Age 18 to 50 years. - Medically stable - Spinal Cord Injury =T3 - American Spinal Injury Association grade A or B or C. - Able to perform arm crank exercise. Exclusion Criteria: - Cardiomyopathy - High blood pressure( >140/90 mmHg or you are taking high blood pressure medication) - Significant irregular heartbeat - Heart disease - Chronic lung disease (COPD, bronchitis) - Current use of cardioactive or antidepressant drugs - Family history of significant irregular heart beat or sudden cardiac death - Orthostatic hypotension (symptomatic fall in blood pressure >30 mmHg when upright) - Current grade 2 or greater pressure ulcers at relevant contact site - Neurological disease (stroke, peripheral neuropathy, myopathy) - Arm or shoulder conditions that limit ability to perform arm crank exercise - History of bleeding disorder, diabetes, kidney disease, cancer, other neurological disease - Recent weigh change (greater than 10 pounds) - Regular use of tobacco - Intrathecal baclofen pump, - Current use of cardioactive, antidepressant, other sedating agents - Suicidal ideation - Pregnant and/or breastfeeding women. In addition, subjects must have no known hypersensitivity to Buspar and must not be taking a monoamine oxidase inhibitor. |
Country | Name | City | State |
---|---|---|---|
United States | Spaulding Hospital Cambridge | Cambridge | Massachusetts |
Lead Sponsor | Collaborator |
---|---|
Spaulding Rehabilitation Hospital |
United States,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Pulmonary Function | A change in FEV1 | 14 Days | |
Primary | Hypercapnic Ventilatory Response | A change in the drive to breathe with a change in carbon dioxide | 14 Days | |
Primary | Sleep Quality | A change in sleep apneas | 14 Days | |
Primary | Exercise Pulmonary Capacity | Change in peak oxygen consumption during exercise | 14 Days |
Status | Clinical Trial | Phase | |
---|---|---|---|
Active, not recruiting |
NCT06321172 -
Muscle and Bone Changes After 6 Months of FES Cycling
|
N/A | |
Completed |
NCT03457714 -
Guided Internet Delivered Cognitive-Behaviour Therapy for Persons With Spinal Cord Injury: A Feasibility Trial
|
||
Recruiting |
NCT05484557 -
Prevention of Thromboembolism Using Apixaban vs Enoxaparin Following Spinal Cord Injury
|
N/A | |
Suspended |
NCT05542238 -
The Effect of Acute Exercise on Cardiac Autonomic, Cerebrovascular, and Cognitive Function in Spinal Cord Injury
|
N/A | |
Recruiting |
NCT05503316 -
The Roll of Balance Confidence in Gait Rehabilitation in Persons With a Lesion of the Central Nervous System
|
N/A | |
Not yet recruiting |
NCT05506657 -
Early Intervention to Promote Return to Work for People With Spinal Cord Injury
|
N/A | |
Recruiting |
NCT04105114 -
Transformation of Paralysis to Stepping
|
Early Phase 1 | |
Recruiting |
NCT03680872 -
Restoring Motor and Sensory Hand Function in Tetraplegia Using a Neural Bypass System
|
N/A | |
Completed |
NCT04221373 -
Exoskeletal-Assisted Walking in SCI Acute Inpatient Rehabilitation
|
N/A | |
Completed |
NCT00116337 -
Spinal Cord Stimulation to Restore Cough
|
N/A | |
Completed |
NCT03898700 -
Coaching for Caregivers of Children With Spinal Cord Injury
|
N/A | |
Recruiting |
NCT04883463 -
Neuromodulation to Improve Respiratory Function in Cervical Spinal Cord Injury
|
N/A | |
Active, not recruiting |
NCT04881565 -
Losing Balance to Prevent Falls After Spinal Cord Injury (RBT+FES)
|
N/A | |
Completed |
NCT04864262 -
Photovoice for Spinal Cord Injury to Prevent Falls
|
N/A | |
Recruiting |
NCT04007380 -
Psychosocial, Cognitive, and Behavioral Consequences of Sleep-disordered Breathing After SCI
|
N/A | |
Active, not recruiting |
NCT04544761 -
Resilience in Persons Following Spinal Cord Injury
|
||
Terminated |
NCT03170557 -
Randomized Comparative Trial for Persistent Pain in Spinal Cord Injury: Acupuncture vs Aspecific Needle Skin Stimulation
|
N/A | |
Completed |
NCT03220451 -
Use of Adhesive Elastic Taping for the Therapy of Medium/Severe Pressure Ulcers in Spinal Cord Injured Patients
|
N/A | |
Recruiting |
NCT04811235 -
Optical Monitoring With Near-Infrared Spectroscopy for Spinal Cord Injury Trial
|
N/A | |
Recruiting |
NCT04736849 -
Epidural and Dorsal Root Stimulation in Humans With Spinal Cord Injury
|
N/A |