Spinal Cord Injuries Clinical Trial
Official title:
Daily Intermittent Hypoxia and Task-Specific Upper Limb Training in Persons With Chronic Incomplete SCI
The purpose of this research study is to investigate the effectiveness of a combinatorial
therapy of breathing low oxygen in short bursts-acute intermittent hypoxia (AIH) and upper
limb training on arm strength and function, and comparing it with individual treatments in
persons with spinal cord injuries.
The investigators hypothesize that a combinatorial intervention with AIH therapy + upper limb
training will be significantly more effective in improving hand function, compared to
individual treatments alone.
To test this hypothesis, the investigators will determine the impact of combined daily AIH
therapy and high-repetition task-specific upper extremity training on arm strength and hand
dexterity in persons with spinal cord injuries.
The objective of this research project is to determine the effect of a 5-day intervention
with daily acute intermittent hypoxia (AIH) therapy, either alone or coupled with
task-specific training, on upper extremity function in individuals with chronic, incomplete
SCI.
Previous work already determined that breathing low levels of oxygen for short periods of
time (also known as acute intermittent hypoxia) can improve lower limb motor function in
persons with spinal injury. Specifically, this study is being done to determine if
pre-treatment with intermittent hypoxia can enhance the beneficial effects of upper limb
training on the restoration of limb function in persons with spinal injury.
This is a blinded study, which means that the subject will not know which treatment they are
receiving. They will either receive intermittent periods of low oxygen (hypoxia) or a session
composed of only normal room air. They will be randomly assigned to a treatment based on
chance. Neither the subject nor the researcher chooses the assigned group. They will have an
equal chance of being in either group.
The participant will receive a daily 5-day intervention with either acute intermittent
hypoxia (AIH) therapy or room air, either alone or coupled with task-specific training, on
upper extremity function in individuals with chronic, incomplete SCI. This will be preceded
by a baseline testing visit prior to the intervention, and followed by a 4 week follow up
period to assess the effects of the interventions over time.
The total duration of participation in the study intervention protocol is 1 week. Including
the follow up period, the subjects will participate for a total of 6 weeks.
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