Spinal Cord Injuries Clinical Trial
Official title:
Melatonin Secretion and Sleep Quality in Spinal Cord Injury Patients
To evaluate the relationship between secretion of melatonin and sleep quality in spinal cord injury patients versus a database of healthy volunteers.
Melatonin is a neurohormone secreted by the pineal gland and excreted by the urinary tract.
It has a key role in the synchronisation of circadian rhythms including the sleep wake cycle,
with a peak secretion around 03:00.
The neural pathway controlling melatonin secretion is long and transits via the thoracic
spine. The exact level is not known, but interruption of the connection in patients with
lesions of the spinal cord is known to occur.
Tetraplegic patients often complain of insomnia, daytime sleepiness and poor sleep quality
but the contribution of melatonin levels to sleep quality has not been explored in large
studies, although case reports have shown reduced or abolished melatonin secretion and
altered melatonin secretion profiles with delayed peak secretion. Paraplegic patients report
fewer sleep difficulties and little is known about melatonin secretion in this group. The
investigators hypothesize that sleep abnormalities are related to abnormalities in melatonin
secretion and that this is in turn related to the level of the spinal cord injury
The study aims to explore the profiles of melatonin secretion in patients with spinal cord
injuries and comparing melatonin profiles with a database of healthy volunteers. The
investigators will further analyse the results looking at the severity of spinal cord injury
using the Abbreviated Injury Scale (AIS) and the level of the injury. Outcome measures are
melatonin secretion profile, sleep complaints measured using the Pittsburgh scale and daytime
sleepiness measured using the Epworth sleep scale.
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