Spinal Anesthesia Clinical Trial
Official title:
Intrathecal Injection of Hyperbaric Bupivacaine Versus a Mixture of Hyperbaric and Isobaric Bupivacaine in Patients Undergoing Lower Abdominal Surgery: A Randomized Controlled Trial
The aim of this study is to compare the effects of intrathecal injection of hyperbaric bupivacaine versus injection of hyperbaric and isobaric bupivacaine in patients undergoing lower abdominal surgery.
Spinal anesthesia is one of the most commonly used nerve block procedures for surgical operations involving the lower abdomen, the perineum, and the lower limbs, owing to its quick effect and cost-effectiveness. Spinal anesthesia is advantageous in that it uses a small dose of anesthesia, is simple to perform, and offers a rapid onset of action, reliable surgical analgesia, and good muscle relaxation. The Baricity of a solution is defined as the ratio of the density of the solution to that of the cerebrospinal fluid (CSF). The most common anesthetic used for SA in obstetric and non-obstetric surgery is bupivacaine, which can be formulated as an isobaric or hyperbaric solution. Baricity differences between spinal anesthetic solutions are thought to affect hemodynamic parameters and distribution within the subarachnoid space, which may, in turn, affect the onset, extent, and duration of sensory block as well as side effects. Spinal anesthesia has been linked to different adverse effects, out of which hypotension is most common complication. The incidence of hypotension is 25-75% in general population. Factors that increase the risk of hypotension include patient factors (advanced age, pregnancy, obesity, diabetes mellitus, hypertension, and anemia) and technical factors such as a block level at or above T5, use of opioids during premedication, and high local anesthetic dosages. ;
Status | Clinical Trial | Phase | |
---|---|---|---|
Completed |
NCT02565303 -
Minimum Effective Dose of Ropivacaine for Spinal Anesthesia for Cesarean Delivery
|
N/A | |
Recruiting |
NCT03248817 -
Phenylephrine Infusion in Cesarean Delivery
|
Phase 4 | |
Completed |
NCT02840006 -
Spinal Anesthesia Associated With General Anesthesia in Coronary Artery Bypass
|
Phase 4 | |
Completed |
NCT01624844 -
Predictive Value of Ultrasound Measurement of the Dural Sac Volume on the Sensory Level in Spinal Anesthesia
|
N/A | |
Recruiting |
NCT00974961 -
Levobupivacaine on Heart Rate Variability (HRV) in Spinal Anesthesia
|
Phase 4 | |
Recruiting |
NCT00492453 -
Spinal Versus General Anesthesia for Laparoscopic Cholecystectomy
|
N/A | |
Completed |
NCT05549011 -
PENG vs SIFI Block for Positioning Pain During Spinal Anesthesia
|
||
Completed |
NCT03805503 -
Chloroprocaine for Inguinal Herniorrhaphy
|
Phase 4 | |
Completed |
NCT03775655 -
Low Dose Hyperbaric Bupivacaine and Dexmedetomidine as an Adjuvant, Caesarean Section
|
Phase 2/Phase 3 | |
Completed |
NCT03199170 -
Effect of Bilateral Quadratus Lumborum Block for Pain Relief in Patients With Cesarean Section
|
N/A | |
Completed |
NCT03302039 -
Three Protocols for Phenylephrine Administration in Cesarean Delivery
|
Phase 4 | |
Not yet recruiting |
NCT05063292 -
Effect of Prewarming On Skin Temperature Changes
|
N/A | |
Not yet recruiting |
NCT05583214 -
Evaluating the Effectiveness of Ondansetron Versus Dexamethasone Versus Placebo for the Control of Intraoperative Nausea and Vomiting in Patients Undergoing Lower-segment Caesarean Section Under Spinal Anesthesia
|
Phase 4 | |
Recruiting |
NCT02937792 -
Large Volume Bupivacaine 0.5% Versus Small Volume in Elective Caesarean Section
|
N/A | |
Recruiting |
NCT01415284 -
ED50 Determination of Hydroxyethylstarch for Treatment of Hypotension During Cesarean Section Under Spinal Anesthesia
|
Phase 4 | |
Completed |
NCT00537472 -
Low Dose Spinal Bupivacaine for Total Knee Replacement and Recovery Room Wait Time
|
N/A | |
Completed |
NCT05548985 -
Midodrine for Prophylaxis Against Post Spinal Hypotension in Elderly Population
|
N/A | |
Completed |
NCT03322098 -
Effect of Atropine or Glycopyrrolate on the Prevention of Bradycardia During Sedation Using Dexmedetomidine in Geriatric Patients Undergoing Total Knee Replacement Under Spinal Anesthesia
|
N/A | |
Recruiting |
NCT04598061 -
IV Dexmedetomidine as Spinal Anesthesia Adjuvant in Infants
|
||
Completed |
NCT04083768 -
Effect of Different Left Lateral Table Tilt for Elective Cesarean Delivery Under Spinal Anesthesia
|
N/A |