Spinal Anaesthesia Clinical Trial
Official title:
Crystalloids Versus Colloids Versus Hypertonic Saline Co-load During Spinal Anesthesia: Which is More Effective
Verified date | September 2018 |
Source | National Cancer Institute, Egypt |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
Spinal anesthesia is commonly accompanied by hypotension due to vasodilation that follows sympathetic blockade and decreased systemic vascular resistance. Prevention of hypotension is usually achieved through administration of fluids and vasopressors .There is an ongoing debate concerning both the proper fluid timing, pre-load against co-load and fluid type crystalloids against colloids .This study aims at comparing the effectiveness of co-loading of crystalloids versus colloids versus hypertonic saline 3% in preventing hypotension induced by spinal anesthesia.
Status | Completed |
Enrollment | 120 |
Est. completion date | August 30, 2018 |
Est. primary completion date | August 30, 2018 |
Accepts healthy volunteers | No |
Gender | All |
Age group | 18 Years to 65 Years |
Eligibility |
Inclusion Criteria: - Age 18-65 years - ASA II-III - Elective lower abdominal surgeries Exclusion Criteria: - Coagulation defects - Abnormal kidney or liver functions - Local infection at site of injection - Uncontrolled hypertension - Bone metastases - Cardiac disease - Elevated serum sodium level > 145 mEq/L |
Country | Name | City | State |
---|---|---|---|
Egypt | Department of Anesthesia and Pain medicine.National Cancer Institute | Cairo |
Lead Sponsor | Collaborator |
---|---|
National Cancer Institute, Egypt |
Egypt,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Hypotension | The development of hypotension | 3 hours | |
Secondary | serum sodium level | measurement of serum sodium level | 3 hours |
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