Clinical Trials Logo

Clinical Trial Summary

The proposed project we intend to assess the implication of the telomeric pathway in male infertility. To get this, several analyzes will be carried out: 1. Determination of the TL by means of two methods: Q-FISH and PCR. 2. Determination of sperm DNA fragmentation by tunnel technique. 3. Assess sperm maturation. Finally, the correlations between age, normality or not of the seminogram, LT, Short telomers (ST) accumulation, DNA fragmentation levels, sperm maturation and fertility, blastocyst development, and pregnancy rates will be established in search of cut-off points that can give a forecast of man´s fertility who consults on this subject.


Clinical Trial Description

To carry out the project, men who come to the clinic in the context of a couple fertility study and who do not have a known cause that justifies their infertility will be recruited. A clinical history will be made, and an informed consent will be given to them for their participation in the project (Annex Consents). Semen samples will be obtained on the day of oocyte fertilization and the unused part of the sample is recovered for Sperm LT determination, ST accumulation, sperm DNA fragmentation and sperm maturation. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT05508217
Study type Observational
Source IVI Madrid
Contact Carlos Balmori Boticario, PhD
Phone +34 180 29 00
Email Carlos.Balmori@ivirma.com
Status Recruiting
Phase
Start date August 22, 2022
Completion date December 1, 2024

See also
  Status Clinical Trial Phase
Recruiting NCT06172504 - Ejaculation Frequency and Semen Parameters
Withdrawn NCT02431000 - Male Fertility and Sperm Cryopreservation
Completed NCT02422108 - TNFSF11 Inhibition and Fertility: a Prospective Study Phase 2
Withdrawn NCT02869425 - To Assess Effects of Arbaclofen ER Tablets Compared With Placebo on Sperm Parameters in Male Subjects With MS Phase 3
Recruiting NCT06243926 - Sperm Selection by Rheotaxis and Thermotaxis in In-Situ Handmade Microfluidics of Fluidic Walls in the Same ICSI Plate
Completed NCT01368484 - Effect of Dietary DHA Supplementation on Sperm Quality N/A
Completed NCT03153436 - The Effect of In-vitro Myoinositol Supplementation of Human Sperm on the Outcome of Cryopreservation Phase 1/Phase 2