Sperm Capacitation Assay as a Tool to Predict Sperm Potential to Fertilize in IVF Treatment

Sperm Capacitation Clinical Trial

Official title:

Sperm Capacitation Assay as a Tool to Predict Sperm Potential to Fertilize in IVF Treatment

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT00731159
• Other study ID #: 54/08
• Status: Recruiting
• Phase: N/A
• First received: August 7, 2008
• Last updated: August 7, 2008
• Start date: July 2008
• Est. completion date: July 2009

Study information

• Verified date: July 2008
• Source: Assaf-Harofeh Medical Center
• Contact: arieh raziel, prof
• Phone: 97289779005
• Email: araziel[@]asaf.health.gov.il
• Is FDA regulated: No
• Health authority: Israel: Assaf Harofeh "Helsinky" review board
• Study type: Observational

Clinical Trial Summary

Our aim is to evaluate the potential of a new laboratory method that measure sperm capacitation to predict fertilization of oocytes in patients that undergo IVF treatments

Description:

Capacitation is a physiologic process in which the sperm acquire the potential to fertilize oocytes. Capacitation can be measured, but the available technics are expensive, inaccurate and complex. A new method to evaluate sperm capacitation was developed in Bar Ilan University, Israel. We intend to measure the capacitation of semen that is used for fertilizing human oocytes in patients treated at the IVF unit at Assaf Harofeh Medical Center.By this, to evaluate the potential of the new method to predict human oocyte fertilization.If the method will be found valuable, it will enable to develop new drugs/methods that may improve sperm capacitation and by this to improve oocyte fertilization leading to more embryos, pregnancies and deliveries.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 50
• Est. completion date: July 2009
• Est. primary completion date: January 2009
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years to 40 Years

Eligibility

Inclusion Criteria:

• Patients requiring IVF within the "routine" work of an IVF Unit

• normo-responding woman

• non ICSI cycles

Exclusion Criteria:

• Patients undergoing ICSI only cycle

• Low responders-less than 8 oocytes

• Male patients with low semen volume

Study Design

Time Perspective: Prospective

Related Conditions & MeSH terms

• Sperm Capacitation

Intervention

Biological:
• sperm capacitation
sperm capacitation measured at Bar Ilan University

Other:
• biologic
sperm synthesis of G-actine to F-actine
• sperm capacitation
sperm synthesis of G-actine to F-actine

Locations

Country	Name	City	State
Israel	Assaf Harofeh MC	Beer Yaacov	Zerifin

Sponsors (1)

Lead Sponsor	Collaborator
Assaf-Harofeh Medical Center

Country where clinical trial is conducted

Israel, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Fertilization rate of human oocytes in thr "routine" IVF Laboratory work		One year	No