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Speech Motor Learning and Retention (Master Protocol)

Speech Clinical Trial

Official title:
Sensorimotor Basis of Speech Motor Learning and Retention

Clinical Trial Summary

The overall goal of this research is to test a new model of speech motor learning, whose central hypothesis is that learning and retention are associated with plasticity not only in motor areas of the brain but in auditory and somatosensory regions as well.

Clinical Trial Description

Aim 1 involves tests of speech motor memory retention following disruption of left hemisphere brain activity in either auditory, somatosensory or motor cortex or to a control site (hand area motor cortex right hemisphere). Continuous theta-burst stimulation (cTBS) is delivered following adaptation to altered auditory feedback to assess its effects on the retention of new learning. Aim 2 assesses the temporal order in which plasticity occurs in cortical motor and sensory brain areas during speech motor learning. In Aim 3, resting-state fMRI will be interleaved with speech motor adaptation. For information specific to each aim, please refer to the below corresponding, separate, clinicaltrials.gov records: unique IDs: 2000037622_a for Aim 1, 2000037622_b for Aim 2 and 2000037622_c for Aim 3. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06467292
Study type Interventional
Source Yale University
Contact David Ostry
Phone 2038656163
Email david.ostry@yale.edu
Status Not yet recruiting
Phase N/A
Start date July 2024
Completion date July 2027
View Details
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