Dynamic Neural Mechanisms of Audiovisual Speech Perception

Speech Perception Clinical Trial

Official title:

Dynamic Neural Mechanisms of Audiovisual Speech Perception

Clinical Trial Details — Status: Enrolling by invitation

Administrative data

• NCT number: NCT04290130
• Other study ID #: 844668
• Status: Enrolling by invitation
• Phase: Early Phase 1
• Start date: September 15, 2019
• Est. completion date: May 31, 2024

Study information

• Verified date: October 2023
• Source: University of Pennsylvania
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Understanding speech is one of the most important functions of the human brain. We use information from both the auditory modality (the voice the of person we are talking to) and the visual modality (the facial movements of the person we are talking to) to understand speech. We will use intracranial encephalography to study the organization and operation of the brain during audiovisual speech perception.

Recruitment information / eligibility

• Status: Enrolling by invitation
• Enrollment: 100
• Est. completion date: May 31, 2024
• Est. primary completion date: May 31, 2024
• Accepts healthy volunteers: No
• Gender: All
• Age group: 21 Years to 65 Years

Eligibility

Inclusion Criteria:

• must be undergoing neurosurgery for the treatment of a brain disorder

Exclusion Criteria:

• must have corrected-to-normal vision and hearing

Related Conditions & MeSH terms

• Speech Perception

Intervention

Other:
• Measurement of brain activity using electrodes.
We will present audiovisual speech and record neural responses.

Locations

Country	Name	City	State
United States	University of Pennsylvania	Philadelphia	Pennsylvania

Sponsors (3)

Lead Sponsor	Collaborator
University of Pennsylvania	Baylor College of Medicine, Columbia University

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Measurement of neural activity	The name of the measurement is the broadband high-frequency activity (BHA) in the brain in response to audiovisual speech. The unit of measure is % increase in power from pre-stimulus baseline. The name of the measurement tool is intracranial EEG, recordings of the raw voltage signal from each electrode implanted in the brain. The voltage-by-time signal will be converted to spectral space using a wavelet transform, and the magnitude of the power between 70 and 150 Hz inclusive in a time window between 0 ms and 500 ms after stimulus onset will be calculated.	During the procedure.