Spasm Clinical Trial
Official title:
Dual-acquisition of Noninvasive Cardiac Imaging in Vasospastic Angina Korean Registry
With regard to the characteristics of spasm segment, had been clearly described by other
invasive imaging methods including intravascular ultrasound and optical coherence tomography.
However, there is potential risk during these invasive procedures, such as severe myocardial
ischemia or fatal arrhythmia.
Presently available imaging test for coronary artery disease in multi detector-row computed
tomography angiography (MDCTA) evaluation has high diagnostic accuracy to evaluate coronary
artery stenosis. However, previous report assessing imaging findings or diagnostic accuracy
of MDCTA in patients with vasospastic angina (VSA) is lacking.
Previously investigators analyzed the characteristics of coronary spasm segment in an
observational individual dataset, suspected VSA patients (n=20) underwent dual-acquisition of
MDCTA (initial and intravenous nitrate injected CT imaging), the diagnostic accuracy showed
sensitivity: 73%, specificity: 100%, positive predictive value: 100%, and negative predictive
value: 56%.
Further study is necessary because previous analysis presented limited sample size and
deficiency of healthy control.
Therefore, investigators hypothesis that dual-acquisition of MDCTA in noninvasive tool for
coronary assessment provide more information of coronary characteristics, and the diagnostic
efficacy would be non-inferior as compared with the invasive coronary imaging modality in
coronary spasm-induced angina attacks.
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